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Cationic phosphonolipids containing quaternary phosphonium and arsonium groups for DNA transfection with good efficiency and low cellular toxicity

Abstract : Replacing the ammonium polar head in cationic lipids 1 (A = N) by a phosphonium or an arsonium group (A=P, As) improves their properties as synthetic vectors for DNA transfection. The increased volume of the cationic head is supposed to modify the interactions of the vector with the solvent and DNA.
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https://hal.univ-brest.fr/hal-01771351
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Submitted on : Thursday, April 19, 2018 - 2:48:25 PM
Last modification on : Tuesday, November 3, 2020 - 9:50:05 AM

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E. Guénin, A.-C. Hervé, V. Floch, S. Loisel, J.-J. Yaouanc, et al.. Cationic phosphonolipids containing quaternary phosphonium and arsonium groups for DNA transfection with good efficiency and low cellular toxicity. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2000, 39, pp.629--631. ⟨10.1002/(SICI)1521-3773(20000204)39:3<629::AID-ANIE629>3.0.CO;2-K⟩. ⟨hal-01771351⟩

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