Cationic phosphonolipids containing quaternary phosphonium and arsonium groups for DNA transfection with good efficiency and low cellular toxicity - Université de Bretagne Occidentale Access content directly
Journal Articles Angewandte Chemie International Edition Year : 2000

Cationic phosphonolipids containing quaternary phosphonium and arsonium groups for DNA transfection with good efficiency and low cellular toxicity

Abstract

Replacing the ammonium polar head in cationic lipids 1 (A = N) by a phosphonium or an arsonium group (A=P, As) improves their properties as synthetic vectors for DNA transfection. The increased volume of the cationic head is supposed to modify the interactions of the vector with the solvent and DNA.

Dates and versions

hal-01771351 , version 1 (19-04-2018)

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E. Guénin, A.-C. Hervé, V. Floch, S. Loisel, J.-J. Yaouanc, et al.. Cationic phosphonolipids containing quaternary phosphonium and arsonium groups for DNA transfection with good efficiency and low cellular toxicity. Angewandte Chemie International Edition, 2000, 39, pp.629--631. ⟨10.1002/(SICI)1521-3773(20000204)39:3<629::AID-ANIE629>3.0.CO;2-K⟩. ⟨hal-01771351⟩
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