Triggering bilayer to inverted-hexagonal nanostructure formation by thiol–ene click chemistry on cationic lipids: consequences on gene transfection
Résumé
The ramification of cationic amphiphiles on their unsaturated lipid chainsisreadilyachievedbyusingthethiol–eneclickreactiontriggering the formation of an inverted hexagonal phase (HII). The new ramified cationic lipids exhibit different bio-activities (transfection, toxicity) including higher transfection efficacies on 16HBE 14o-cell lines.