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Triggering bilayer to inverted-hexagonal nanostructure formation by thiol–ene click chemistry on cationic lipids: consequences on gene transfection

Abstract : The ramification of cationic amphiphiles on their unsaturated lipid chainsisreadilyachievedbyusingthethiol–eneclickreactiontriggering the formation of an inverted hexagonal phase (HII). The new ramified cationic lipids exhibit different bio-activities (transfection, toxicity) including higher transfection efficacies on 16HBE 14o-cell lines.
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https://hal.univ-brest.fr/hal-01517791
Contributor : Hélène Couthon <>
Submitted on : Wednesday, May 3, 2017 - 4:15:35 PM
Last modification on : Wednesday, July 8, 2020 - 12:42:40 PM

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Damien Afonso, Tony Le Gall, Hélène Couthon, Axelle Grélard, Shipra Prakash, et al.. Triggering bilayer to inverted-hexagonal nanostructure formation by thiol–ene click chemistry on cationic lipids: consequences on gene transfection. Soft Matter, Royal Society of Chemistry, 2016, 12 (20), pp.4516 - 4520. ⟨10.1039/c6sm00609d⟩. ⟨hal-01517791⟩

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