Triggering bilayer to inverted-hexagonal nanostructure formation by thiol–ene click chemistry on cationic lipids: consequences on gene transfection

Abstract : The ramification of cationic amphiphiles on their unsaturated lipid chainsisreadilyachievedbyusingthethiol–eneclickreactiontriggering the formation of an inverted hexagonal phase (HII). The new ramified cationic lipids exhibit different bio-activities (transfection, toxicity) including higher transfection efficacies on 16HBE 14o-cell lines.
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Article dans une revue
Soft Matter, Royal Society of Chemistry, 2016, 12 (20), pp.4516 - 4520. 〈10.1039/c6sm00609d〉
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http://hal.univ-brest.fr/hal-01517791
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Soumis le : mercredi 3 mai 2017 - 16:15:35
Dernière modification le : mercredi 28 février 2018 - 15:20:15

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Damien Afonso, Tony Le Gall, Hélène Couthon, Axelle Grélard, Shipra Prakash, et al.. Triggering bilayer to inverted-hexagonal nanostructure formation by thiol–ene click chemistry on cationic lipids: consequences on gene transfection. Soft Matter, Royal Society of Chemistry, 2016, 12 (20), pp.4516 - 4520. 〈10.1039/c6sm00609d〉. 〈hal-01517791〉

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