Salivary gland ultrasonography improves the diagnostic performance of the 2012 American College of Rheumatology classification criteria for Sjögren's syndrome.

Divi Cornec 1, 2 Sandrine Jousse-Joulin 1, 2 Thierry Marhadour 1, 2 Jacques-Olivier Pers 1 Sylvie Boisramé-Gastrin 3 Yves Renaudineau 1 Alain Saraux 1, 2 Valérie Devauchelle-Pensec 1, 2
1 EA2216 - Immunologie et Pathologie
2 CHU - BREST - Rhumato - CHRU Brest - Service de Rhumatologie
3 LUBEM - Laboratoire Universitaire de Biodiversité et Ecologie Microbienne
Abstract : OBJECTIVE: The aim of this study was to evaluate whether salivary gland ultrasonography (SGUS) improves the diagnostic performance of the 2012 ACR classification criteria for SS. METHODS: We studied a cohort of 101 patients with suspected SS seen at a single centre in Brittany, France. An SGUS echostructure score ≥2 was considered abnormal. The reference standard was a clinical diagnosis of SS made by a group of experts blinded to SGUS findings. RESULTS: SS was diagnosed in 45 patients. Similar proportions of patients with and without SS had an ocular staining score ≥3. Adding RF positivity and ANA titre ≥1:320 as an alternative to anti-SSA/SSB positivity increased the sensitivity of the serological item without modifying specificity compared with using anti-SSA/SSB alone. SGUS was 60.0% sensitive and 87.5% specific for SS. Adding the SGUS score to the ACR criteria increased sensitivity from 64.4% to 84.4% and only slightly decreased specificity, from 91.1% to 89.3%. CONCLUSION: The diagnostic performance of the ACR classification criteria for SS is notably improved by adding the SGUS score. SGUS should be included in future classification criteria for SS.
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Article dans une revue
Rheumatology, Oxford University Press (OUP), 2014, 53 (9), pp.1604-7. 〈10.1093/rheumatology/keu037〉
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http://hal.univ-brest.fr/hal-01065884
Contributeur : Geneviève Michel <>
Soumis le : jeudi 18 septembre 2014 - 16:25:08
Dernière modification le : mercredi 10 janvier 2018 - 14:42:39

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UNIV-BREST | LUBEM | IMMUNO

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Divi Cornec, Sandrine Jousse-Joulin, Thierry Marhadour, Jacques-Olivier Pers, Sylvie Boisramé-Gastrin, et al.. Salivary gland ultrasonography improves the diagnostic performance of the 2012 American College of Rheumatology classification criteria for Sjögren's syndrome.. Rheumatology, Oxford University Press (OUP), 2014, 53 (9), pp.1604-7. 〈10.1093/rheumatology/keu037〉. 〈hal-01065884〉

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