Melkersson-Rosenthal syndrome is described as a syndrome which associates three cardinal signs: peripheral facial paralysis, facial oedema, and fissured tongue. These signs are rarely all present. A range of other symptoms are associated with its, making the diagnosis difficult. We report a case of a twenty-five-year-old women presented recurrent facial paresis and clinical dry syndrome since several years. The facial paresis was secondarily accompanied by headache. After a complete dermatological examination, a Melkersson-Rosenthal syndrome has been suspected. Several treatments have been tried, reducing the symptoms, without making them disappear. The Melkersson-Rosenthal syndrome is well known, but the characteristic triad is rarely present in its entirety. This syndrome is accompanied by a multitude of other symptoms of neurovegetative origin for the most part, and sometimes with autoimmune disorders, which can induce diagnostic delay and/or misdiagnosis.