Given the need for water use to be a crucial consideration in sustainable development, an adequate water allocation system across economic sectors is essential, especially in the face of increasing seasonal and perennial water scarcity. In an attempt to facilitate a socially and economically efficient adaptation to the climate emergency, we propose a set of eleven socio-economic indicators to analyze the current water management. This set of indicators could help to quantify the interrelationship between water use and its economic perspective, as well as its social perspective through its impact on employment. Any demand for water not only includes the direct use of water but also its indirect use, referred to as virtual water. This is the water indirectly used through the other inputs in the production process (input–output methodology). These indicators are evaluated in the South-West Europe territory where, in light of increasing water scarcity, there is a need to orientate water allocation toward employment with less intensive water use, to more water productivity and to less environmental impacts. The results at river basin scales show that water use is more productive in the tertiary than in the secondary and primary sectors.