Sargassum C. Agardh is a highly diverse genus within the brown algae, with 615 currently recognized species, varieties and forms worldwide. This high level of species diversity led early taxonomists, using morphological-anatomical criteria only, to divide the genus into up to five sub-genera and several lower-ranking taxonomic units (e.g., sections, tribes). With the advent of molecular data, subsequent authors revised this complex and archaic classification, with the genus now comprising only two sub-genera: Sargassum and Bactrophycus. Whilst most Sargassum species are benthic, only two are known to be holopelagic and responsible for strandings along tropical Atlantic coasts. The rest of the genus is cosmopolitan, occurring from tropical to temperate regions. Sargassum has not yet been reported in polar regions. Where Sargassum is present, macroalgal populations can grow in large quantities, and the resulting biomass can be valuable to the local communities for a variety of uses. Here we review the genus Sargassum from a taxonomic, ecological and physiological perspectives, and explore the different ways of taking advantage of this extraordinary biomass, which while becoming an invasive pest in some countries, could represent opportunities for coastal populations worldwide.