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Ruthenium(II) Polypyridyl Complexes as Photosensitizers for Antibacterial Photodynamic Therapy: A Structure-Activity Study on Clinical Bacterial Strains

Abstract : As a growing public health concern, the worldwide spread of antimicrobial resistance urges the development of new therapies. Antibacterial photodynamic therapy (a‐PDT) may be an alternative to conventional antibiotic therapy. Herein we report the synthesis and characterization of seven original reactive oxygen species (ROS)‐producing ruthenium(II) polypyridyl complexes. These are part of a collection of 17 derivatives varying in terms of the nature of the substituent(s), molecular symmetry, electrical charge, and counterions. They were characterized by considering 1) their physical properties (absorption coefficient at irradiation wavelength, 1O2 generation quantum yield, luminescence) and 2) their antibacterial activity in a series of photodynamic assays using Gram‐positive and Gram‐negative bacteria of clinical relevance. The results unveiled some structure–activity relationships: one derivative that combines multiple beneficial features for a‐PDT was effective against all the bacteria considered, regardless of their Gram status, species, or antibiotic resistance profile. This systematic study could guide the design of next‐generation ruthenium‐based complexes for enhanced antibacterial photodynamic strategies.
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https://hal.univ-brest.fr/hal-02464633
Contributor : Nicolas Renard <>
Submitted on : Monday, February 3, 2020 - 12:55:01 PM
Last modification on : Tuesday, February 4, 2020 - 1:34:39 AM

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Tony Le gall, Gilles Lemercier, Sylviane Chevreux, Katrin-Stephanie Tücking, Julian Ravel, et al.. Ruthenium(II) Polypyridyl Complexes as Photosensitizers for Antibacterial Photodynamic Therapy: A Structure-Activity Study on Clinical Bacterial Strains. ChemMedChem, Wiley-VCH Verlag, 2018, 13 (20), pp.2229-2239. ⟨10.1002/cmdc.201800392⟩. ⟨hal-02464633⟩

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