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Non-secretory breast carcinomas lack NTRK rearrangements and TRK protein expression

Abstract : Anti-TRK targeted therapies offer opportunities to treat patients with advanced NTRK1/2/3-rearranged cancers. Beyond NTRK-rearranged secretory breast carcinomas, little is known about NTRK rearrangements and the expression of TRK proteins in non-secretory breast carcinomas. We search for TRK proteins expressions using pan-TRK immunohistochemistry and NTRK1, NTRK2 and NTRK3 rearrangements using fluorescent in situ hybridization (FISH) tests in a set of tissue microarray included breast carcinomas. Only 1/339 invasive breast carcinomas, the only example of secretory subtype, was positive using pan-TRK immunohistochemistry and harboured a NTRK-rearrangement (NTRK1 positive FISH test). According to our results, druggable NTRK rearrangements and related-TRK proteins expression are not encountered in non-secretory breast carcinomas.
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Contributor : Geneviève Michel Connect in order to contact the contributor
Submitted on : Friday, August 2, 2019 - 3:29:47 PM
Last modification on : Tuesday, November 29, 2022 - 5:10:07 PM




Annabelle Remoué, Virginie Conan-Charlet, Amélie Bourhis, Glen Le Flahec, Laetitia Lambros, et al.. Non-secretory breast carcinomas lack NTRK rearrangements and TRK protein expression. Pathology International, 2019, 69 (2), pp.94-96. ⟨10.1111/pin.12766⟩. ⟨hal-02262482⟩



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