Non-secretory breast carcinomas lack NTRK rearrangements and TRK protein expression

Annabelle Remoué 1 Virginie Conan-Charlet 1 Amélie Bourhis 1 Glen Le Flahec 1 Laetitia Lambros 1 Pascale Marcorelles 1 Arnaud Uguen 1, 2
1 CHU - AnaPath - CHRU Brest - Laboratoire d'Anatomo-Pathologie
2 LBAI - Lymphocyte B et Auto-immunité
Abstract : Anti-TRK targeted therapies offer opportunities to treat patients with advanced NTRK1/2/3-rearranged cancers. Beyond NTRK-rearranged secretory breast carcinomas, little is known about NTRK rearrangements and the expression of TRK proteins in non-secretory breast carcinomas. We search for TRK proteins expressions using pan-TRK immunohistochemistry and NTRK1, NTRK2 and NTRK3 rearrangements using fluorescent in situ hybridization (FISH) tests in a set of tissue microarray included breast carcinomas. Only 1/339 invasive breast carcinomas, the only example of secretory subtype, was positive using pan-TRK immunohistochemistry and harboured a NTRK-rearrangement (NTRK1 positive FISH test). According to our results, druggable NTRK rearrangements and related-TRK proteins expression are not encountered in non-secretory breast carcinomas.
Keywords : NTRK breast cancer secretory carcinoma
Document type :
Journal articles
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https://hal.univ-brest.fr/hal-02262482
Contributor : Geneviève Michel <>
Submitted on : Friday, August 2, 2019 - 3:29:47 PM
Last modification on : Saturday, August 3, 2019 - 1:40:46 AM

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Annabelle Remoué, Virginie Conan-Charlet, Amélie Bourhis, Glen Le Flahec, Laetitia Lambros, et al.. Non-secretory breast carcinomas lack NTRK rearrangements and TRK protein expression. Pathology International, Wiley, 2019, 69 (2), pp.94-96. ⟨10.1111/pin.12766⟩. ⟨hal-02262482⟩

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