A “Multi‐Heavy‐Atom” Approach Toward Biphotonic Photosensitizers With Improved Singlet Oxygen Generation Properties

Margaux Galland; Tangui Le Bahers; Akos Banyasz; Noëlle Lascoux; Alain Duperray; Alexei Grichine; Raphaël Tripier; Yannick Guyot; Marie Maynadier; Christophe Nguyen; Magali Gary-Bobo; Chantal Andraud; Cyrille Monnereau; Olivier Maury

doi:10.1002/chem.201901047

Journal articles

A “Multi‐Heavy‐Atom” Approach Toward Biphotonic Photosensitizers With Improved Singlet Oxygen Generation Properties

Margaux Galland ¹ Tangui Le Bahers ¹ Akos Banyasz ¹ Noëlle Lascoux ¹ Alain Duperray ² Alexei Grichine ² Raphaël Tripier ³ Yannick Guyot ⁴ Marie Maynadier ⁵ Christophe Nguyen ⁶ Magali Gary-Bobo ⁶ Chantal Andraud ¹ Cyrille Monnereau ¹ Olivier Maury ¹

1 LC - Laboratoire de Chimie - UMR5182

2 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)

3 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique

4 ILM - Institut Lumière Matière [Villeurbanne]

5 NanoMedSyn

6 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]

Abstract : The TACN based gadolinium complex exhibits high two-photon absorption cross-section combined with near-unity 1O2 generation. The very large inter system crossing efficiency induced by the combination of bromine atom and heavy rare-earth element was corroborated with theoretical calculations. The 1O2 generation properties of micellar suspensions under two-photon activation lead to tumour cells death introducing the potential of such structures for theranostic applications

Keywords : TACN Gd Complex Photodynamic Therapy O2 Intersystem crossing Two-photon microscopy Lanthanide

Document type :

Journal articles

Domain :

Chemical Sciences

Chemical Sciences / Coordination chemistry

Chemical Sciences / Organic chemistry

Chemical Sciences / Radiochemistry

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https://hal.univ-brest.fr/hal-02142985
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Submitted on : Wednesday, May 29, 2019 - 8:12:08 AM
Last modification on : Tuesday, September 27, 2022 - 4:44:36 AM

A “Multi‐Heavy‐Atom” Approach Toward Biphotonic Photosensitizers With Improved Singlet Oxygen Generation Properties

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A “Multi‐Heavy‐Atom” Approach Toward Biphotonic Photosensitizers With Improved Singlet Oxygen Generation Properties

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