A “Multi‐Heavy‐Atom” Approach Toward Biphotonic Photosensitizers With Improved Singlet Oxygen Generation Properties

Margaux Galland 1 Tangui Le Bahers 1 Akos Banyasz 1 Noëlle Lascoux 1 Alain Duperray 2 Alexei Grichine 2 Raphaël Tripier 3 Yannick Guyot 4 Marie Maynadier 5 Christophe Nguyen 6 Magali Gary-Bobo 6 Chantal Andraud 1 Cyrille Monnereau 1 Olivier Maury 1
1 LC - Laboratoire de Chimie - UMR5182
2 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
3 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique
4 ILM - Institut Lumière Matière [Villeurbanne]
5 NanoMedSyn
6 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
Abstract : The TACN based gadolinium complex exhibits high two-photon absorption cross-section combined with near-unity 1O2 generation. The very large inter system crossing efficiency induced by the combination of bromine atom and heavy rare-earth element was corroborated with theoretical calculations. The 1O2 generation properties of micellar suspensions under two-photon activation lead to tumour cells death introducing the potential of such structures for theranostic applications
Keywords : Intersystem crossing Two-photon microscopy Lanthanide TACN Gd Complex Photodynamic Therapy O2
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Journal articles
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https://hal.univ-brest.fr/hal-02142985
Contributor : Nicolas Renard <>
Submitted on : Wednesday, May 29, 2019 - 8:12:08 AM
Last modification on : Thursday, December 12, 2019 - 9:58:04 AM

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Margaux Galland, Tangui Le Bahers, Akos Banyasz, Noëlle Lascoux, Alain Duperray, et al.. A “Multi‐Heavy‐Atom” Approach Toward Biphotonic Photosensitizers With Improved Singlet Oxygen Generation Properties. Chemistry - A European Journal, Wiley-VCH Verlag, 2019, ⟨10.1002/chem.201901047⟩. ⟨hal-02142985⟩

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