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cis-diprotected cyclams and cyclens: A new route to symmetrically or asymmetrically 1,4-disubstituted tetraazamacrocycles and to asymmetrically tetrasubstituted derivatives

Abstract : The use of cyclam and cyclen oxamides as intermediates for the synthesis of N1,N4-disubstituted tetraazamacrocycles is reported. This pathway affords a general strategy for the preparation of symmetrically or asymmetrically disubstituted derivatives in good yields. Also these intermediates proved convenient synthons for the preparation of asymmetrically tetrasubstituted macrocycles, leading to a new class of potentially dinucleating ligands. © The Royal Society of Chemistry 1999.
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https://hal.univ-brest.fr/hal-01771403
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Submitted on : Thursday, April 19, 2018 - 2:49:49 PM
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  • HAL Id : hal-01771403, version 1

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F. Bellouard, F. Chuburu, Nelly Kervarec, Ludovic Toupet, Smail Triki, et al.. cis-diprotected cyclams and cyclens: A new route to symmetrically or asymmetrically 1,4-disubstituted tetraazamacrocycles and to asymmetrically tetrasubstituted derivatives. Journal of the Chemical Society - Perkin Transactions 1, 1999, pp.3499--3505. ⟨hal-01771403⟩

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