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Journal articles

Phenylglyoxal for polyamines modification and cyclam synthesis

Abstract : The bis-aminals obtained by tetraamine and phenylglyoxal condensation display various behaviours such as equilibrium between different configurations, rearrangements that lead to lactam derivatives, or amine deprotection. Our investigations about them were focused on three different linear amines, and then extended to polyazacycloalkanes cyclen and cyclam. Cyclam was also synthesised with the bis-aminals issued from condensation of linear polyamines with phenylglyoxal. The lactam derivatives described here were moreover, employed for the mono-N-functionalisation of tetraamines by phenyl-acetic acid group. © 2003 Elsevier Science Ltd. All rights reserved.
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Contributor : Nicolas Renard Connect in order to contact the contributor
Submitted on : Wednesday, April 11, 2018 - 2:59:38 PM
Last modification on : Monday, October 11, 2021 - 2:22:08 PM

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Raphaël Tripier, F. Chuburu, M. Le Baccon, Henri Handel. Phenylglyoxal for polyamines modification and cyclam synthesis. Tetrahedron, Elsevier, 2003, 59 (25), pp.4573-4579. ⟨10.1016/S0040-4020(03)00656-2⟩. ⟨hal-01763908⟩



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