Cationic lipophosphoramidates and lipophosphoguanidines are very efficient for in vivo DNA delivery - Université de Bretagne Occidentale
Article Dans Une Revue Bioconjugate Chemistry Année : 2005

Cationic lipophosphoramidates and lipophosphoguanidines are very efficient for in vivo DNA delivery

E. Picquet
  • Fonction : Auteur
K.L. Ny
  • Fonction : Auteur
P. Delépine
  • Fonction : Auteur
T. Montier
D. Cartier
  • Fonction : Auteur
C. Férec

Résumé

Two new families of cationic lipids were designed and synthesized for gene delivery, namely "lipophosphoramidates" and " lipophosphoguanidines", whose efficiency was noteworthy. The most efficient have an arsonium cation as the polar head, and the unsaturated lipidic tails (e.g. oleyl) gave the better in vivo results (mice lungs). © 2005 American Chemical Society.

Dates et versions

hal-01763763 , version 1 (11-04-2018)

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Citer

E. Picquet, K.L. Ny, P. Delépine, T. Montier, J.-J. Yaouanc, et al.. Cationic lipophosphoramidates and lipophosphoguanidines are very efficient for in vivo DNA delivery. Bioconjugate Chemistry, 2005, 16 (5), pp.1051-1053. ⟨10.1021/bc050097k⟩. ⟨hal-01763763⟩
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