Cationic lipophosphoramidates and lipophosphoguanidines are very efficient for in vivo DNA delivery
Résumé
Two new families of cationic lipids were designed and synthesized for gene delivery, namely "lipophosphoramidates" and " lipophosphoguanidines", whose efficiency was noteworthy. The most efficient have an arsonium cation as the polar head, and the unsaturated lipidic tails (e.g. oleyl) gave the better in vivo results (mice lungs). © 2005 American Chemical Society.
Mots clés
arsenic derivative
guanidine derivative
lipid
lipophosphoguanidine derivative
lipophosphoramidate derivative
phosphoramidic acid derivative
unclassified drug
animal tissue
article
controlled study
drug delivery system
drug efficacy
drug structure
drug synthesis
gene targeting
human
human cell
hydrolysis
mouse
nonhuman
reaction analysis
Amides
Animals
Cations
Cell Line
Cricetinae
DNA
Gene Transfer Techniques
Genes
Reporter
Genetic Vectors
Guanidines
Humans
Lipids
Mice
Molecular Structure
Phosphoric Acids
Phosphorylation