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Cationic lipophosphoramidates and lipophosphoguanidines are very efficient for in vivo DNA delivery

Abstract : Two new families of cationic lipids were designed and synthesized for gene delivery, namely "lipophosphoramidates" and " lipophosphoguanidines", whose efficiency was noteworthy. The most efficient have an arsonium cation as the polar head, and the unsaturated lipidic tails (e.g. oleyl) gave the better in vivo results (mice lungs). © 2005 American Chemical Society.
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https://hal.univ-brest.fr/hal-01763763
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Submitted on : Wednesday, April 11, 2018 - 1:43:23 PM
Last modification on : Monday, October 11, 2021 - 2:22:08 PM

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E. Picquet, K.L. Ny, P. DelÉpine, T. Montier, J.-J. Yaouanc, et al.. Cationic lipophosphoramidates and lipophosphoguanidines are very efficient for in vivo DNA delivery. Bioconjugate Chemistry, American Chemical Society, 2005, 16 (5), pp.1051-1053. ⟨10.1021/bc050097k⟩. ⟨hal-01763763⟩

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