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Journal articles
Copper(II)-dipicolinate-mediated clickable azide-alkyne cycloaddition in water as solvent
Abstract : Copper(II)-dipicolinate complex [CuIIL(H2O)2] (1) (H2L = dipicolinic acid (H2dipic)) was synthesized via oxidation of copper(I) iodide and pyridine-2,6-dicarboxylic acid in water and acetonitrile in the presence of glycine. Complex 1 was characterized by FT-IR and elemental analysis and its structure confirmed by single crystal X-ray analysis. This complex is an efficient precatalyst that mediates azide-alkyne cycloaddition reactions in water at room temperature either in the absence or presence of a reducing agent. Compound 1-mediated azide-alkyne cycloaddition affords alkyl/aryl substituted 1,2,3-triazole heterocycles in a regioselective manner and excellent yields under very mild reaction conditions matching the criteria of greener protocols.
Cited literature [17 references]
https://hal.univ-brest.fr/hal-01701698
Contributor : Nicolas Renard Connect in order to contact the contributor
Submitted on : Wednesday, February 7, 2018 - 10:04:59 AM
Last modification on : Monday, October 11, 2021 - 2:22:08 PM
Contributor : Nicolas Renard Connect in order to contact the contributor
Submitted on : Wednesday, February 7, 2018 - 10:04:59 AM
Last modification on : Monday, October 11, 2021 - 2:22:08 PM
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