Skip to Main content Skip to Navigation
New interface
Journal articles

Synthesis of functionalized alkoxyalkylidene gem-bisphosphonates

Abstract : We report the synthesis of a series of new functionalized bisphosphonates and bisphosphonic acids with an alkoxy group fixed at the geminal carbon, which is proposed to increase their lipophilicity and so their bioavailability. Subsequently, the alkylation of these alkoxy bisphosphonates with allyl bromide is reported. The reactivity of the allyl group has been studied to give access to alkoxy bisphosphonates functionalized by diverse groups including alcohol, aldehyde, carboxylic acid, epoxide and amine.
Document type :
Journal articles
Complete list of metadata
Contributor : NICOLAS RENARD Connect in order to contact the contributor
Submitted on : Friday, September 1, 2017 - 3:30:01 PM
Last modification on : Wednesday, May 25, 2022 - 9:40:03 AM

Links full text




Jean-Pierre Haelters, Hélène Couthon, Alan Le Goff, Gaelle Simon, Bernard Corbel, et al.. Synthesis of functionalized alkoxyalkylidene gem-bisphosphonates. Tetrahedron, 2008, 64 (27), pp.6537 - 6543. ⟨10.1016/j.tet.2008.04.052⟩. ⟨hal-01580463⟩



Record views