Synthesis of nitrogen bicyclic scaffolds: pyrimido[1,2-a]pyrimidine-2,6-diones

Sylvain Grosjean; Smail Triki; Jean-Claude Meslin; Karine Julienne; David Deniaud

doi:10.1016/j.tet.2010.10.059

Synthesis of nitrogen bicyclic scaffolds: pyrimido[1,2-a]pyrimidine-2,6-diones

Sylvain Grosjean ¹ Smail Triki ² Jean-Claude Meslin ¹ Karine Julienne ¹ David Deniaud ¹

1 CEISAM - Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation

2 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique

Abstract : The multi-step synthesis of 1,3,7-trisubstituted pyrimido[1,2-a]pyrimidinediones starting from isothiocyanates is described. These nitrogen bicycles were prepared by an iterative sequence of functionalization/cyclocondensation reactions. [4+2] Cycloaddition reactions took place between diazadienic chains and various acyl chlorides providing sophisticated heterobicycles.

Keywords : 1 3-Diazabutadienes [4+2] Cycloaddition Nitrogen heterocycles Dihydropyrimidinones Methylsulfanyl group

Type de document :

Article dans une revue

Tetrahedron, Elsevier, 2010, 66 (52), pp.9912 - 9924. 〈http://www.sciencedirect.com/science/article/pii/S0040402010015735〉. 〈10.1016/j.tet.2010.10.059〉

Domaine :

Chimie / Chimie organique

Liste complète des métadonnées

http://hal.univ-brest.fr/hal-01577429
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Soumis le : vendredi 25 août 2017 - 16:14:54
Dernière modification le : vendredi 27 juillet 2018 - 16:34:02

Synthesis of nitrogen bicyclic scaffolds: pyrimido[1,2-a]pyrimidine-2,6-diones

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Synthesis of nitrogen bicyclic scaffolds: pyrimido[1,2-a]pyrimidine-2,6-diones

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