Synthesis of nitrogen bicyclic scaffolds: pyrimido[1,2-a]pyrimidine-2,6-diones

Abstract : The multi-step synthesis of 1,3,7-trisubstituted pyrimido[1,2-a]pyrimidinediones starting from isothiocyanates is described. These nitrogen bicycles were prepared by an iterative sequence of functionalization/cyclocondensation reactions. [4+2] Cycloaddition reactions took place between diazadienic chains and various acyl chlorides providing sophisticated heterobicycles.
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http://hal.univ-brest.fr/hal-01577429
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Soumis le : vendredi 25 août 2017 - 16:14:54
Dernière modification le : jeudi 5 avril 2018 - 10:36:48

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Sylvain Grosjean, Smail Triki, Jean-Claude Meslin, Karine Julienne, David Deniaud. Synthesis of nitrogen bicyclic scaffolds: pyrimido[1,2-a]pyrimidine-2,6-diones. Tetrahedron, Elsevier, 2010, 66 (52), pp.9912 - 9924. 〈http://www.sciencedirect.com/science/article/pii/S0040402010015735〉. 〈10.1016/j.tet.2010.10.059〉. 〈hal-01577429〉

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