Synthesis of nitrogen bicyclic scaffolds: pyrimido[1,2-a]pyrimidine-2,6-diones - Université de Bretagne Occidentale Access content directly
Journal Articles Tetrahedron Year : 2010

Synthesis of nitrogen bicyclic scaffolds: pyrimido[1,2-a]pyrimidine-2,6-diones

Abstract

The multi-step synthesis of 1,3,7-trisubstituted pyrimido[1,2-a]pyrimidinediones starting from isothiocyanates is described. These nitrogen bicycles were prepared by an iterative sequence of functionalization/cyclocondensation reactions. [4+2] Cycloaddition reactions took place between diazadienic chains and various acyl chlorides providing sophisticated heterobicycles.
No file

Dates and versions

hal-01577429 , version 1 (25-08-2017)

Identifiers

Cite

Sylvain Grosjean, Smail Triki, Jean-Claude Meslin, Karine Julienne, David Deniaud. Synthesis of nitrogen bicyclic scaffolds: pyrimido[1,2-a]pyrimidine-2,6-diones. Tetrahedron, 2010, 66 (52), pp.9912 - 9924. ⟨10.1016/j.tet.2010.10.059⟩. ⟨hal-01577429⟩
53 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More