Synthesis of nitrogen bicyclic scaffolds: pyrimido[1,2-a]pyrimidine-2,6-diones

Sylvain Grosjean; Smail Triki; Jean-Claude Meslin; Karine Julienne; David Deniaud

doi:10.1016/j.tet.2010.10.059

Journal articles

Synthesis of nitrogen bicyclic scaffolds: pyrimido[1,2-a]pyrimidine-2,6-diones

Sylvain Grosjean ¹ Smail Triki ² Jean-Claude Meslin ¹ Karine Julienne ¹ David Deniaud ¹

1 CEISAM - Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation

2 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique

Abstract : The multi-step synthesis of 1,3,7-trisubstituted pyrimido[1,2-a]pyrimidinediones starting from isothiocyanates is described. These nitrogen bicycles were prepared by an iterative sequence of functionalization/cyclocondensation reactions. [4+2] Cycloaddition reactions took place between diazadienic chains and various acyl chlorides providing sophisticated heterobicycles.

Keywords : 1 3-Diazabutadienes [4+2] Cycloaddition Nitrogen heterocycles Dihydropyrimidinones Methylsulfanyl group

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Journal articles

Domain :

Chemical Sciences / Organic chemistry

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https://hal.univ-brest.fr/hal-01577429
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Synthesis of nitrogen bicyclic scaffolds: pyrimido[1,2-a]pyrimidine-2,6-diones

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Synthesis of nitrogen bicyclic scaffolds: pyrimido[1,2-a]pyrimidine-2,6-diones

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