Investigation of Zr( iv ) and 89 Zr( iv ) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging

François Guérard 1 Yong-Sok Lee 2 Raphaël Tripier 3 Lawrence P. Szajek 4 Jeffrey R. Deschamps 5 Martin W. Brechbiel 1
1 Radiation Oncology Branch - Radioimmune & Inorganic Chemistry Section [Bethesda, MD, USA]
2 Division of Computational Bioscience - Center for Molecular Modeling [Bethesda, MD, USA]
3 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique
4 Positron Emission Tomography Department
5 Center for Bio/Molecular Science and Engineering
Abstract : Single crystal X-ray diffraction shows that Zr(IV) forms an octa-coordinated complex with 4 bidentate hydroxamates whose solution structures were investigated by utilizing density functional theory at the level of B3LYP/DGDZVP. Stability constants obtained by potentiometry were in accordance with the tendency observed when radiolabeling with 89Zr.
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Chemical Communications, Royal Society of Chemistry, 2013, 49 (10), pp.1002 - 1004. 〈http://pubs.rsc.org/en/Content/ArticleLanding/2013/CC/C2CC37549D#!divAbstract〉. 〈10.1039/C2CC37549D〉
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Contributeur : Nicolas Renard <>
Soumis le : mardi 4 juillet 2017 - 15:04:20
Dernière modification le : jeudi 11 janvier 2018 - 06:17:06

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François Guérard, Yong-Sok Lee, Raphaël Tripier, Lawrence P. Szajek, Jeffrey R. Deschamps, et al.. Investigation of Zr( iv ) and 89 Zr( iv ) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging. Chemical Communications, Royal Society of Chemistry, 2013, 49 (10), pp.1002 - 1004. 〈http://pubs.rsc.org/en/Content/ArticleLanding/2013/CC/C2CC37549D#!divAbstract〉. 〈10.1039/C2CC37549D〉. 〈hal-01555852〉

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