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Investigation of Zr( iv ) and 89 Zr( iv ) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging

François Guérard 1 Yong-Sok Lee 2 Raphaël Tripier 3 Lawrence P. Szajek 4 Jeffrey R. Deschamps 5 Martin W. Brechbiel 1 
1 Radiation Oncology Branch - Radioimmune & Inorganic Chemistry Section [Bethesda, MD, USA]
2 Division of Computational Bioscience - Center for Molecular Modeling [Bethesda, MD, USA]
3 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique
4 Positron Emission Tomography Department
5 Center for Bio/Molecular Science and Engineering
Abstract : Single crystal X-ray diffraction shows that Zr(IV) forms an octa-coordinated complex with 4 bidentate hydroxamates whose solution structures were investigated by utilizing density functional theory at the level of B3LYP/DGDZVP. Stability constants obtained by potentiometry were in accordance with the tendency observed when radiolabeling with 89Zr.
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https://hal.univ-brest.fr/hal-01555852
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Submitted on : Tuesday, July 4, 2017 - 3:04:20 PM
Last modification on : Monday, October 11, 2021 - 2:22:08 PM

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François Guérard, Yong-Sok Lee, Raphaël Tripier, Lawrence P. Szajek, Jeffrey R. Deschamps, et al.. Investigation of Zr( iv ) and 89 Zr( iv ) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging. Chemical Communications, 2013, 49 (10), pp.1002 - 1004. ⟨10.1039/C2CC37549D⟩. ⟨hal-01555852⟩

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