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Journal articles
Investigation of Zr( iv ) and 89 Zr( iv ) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging
François Guérard
1
Yong-Sok Lee
2
Raphaël Tripier
3
Lawrence P. Szajek
4
Jeffrey R. Deschamps
5
Martin W. Brechbiel
1
François Guérard 1
Author IdHAL : francois-guerard ResearcherId : http://www.researcherid.com/rid/L-2881-2015 ORCID : https://orcid.org/0000-0001-9795-2785
Yong-Sok Lee 2
Author
Raphaël Tripier 3
Author IdHAL : raphael-tripier ORCID : https://orcid.org/0000-0001-9364-788X
Lawrence P. Szajek 4
Author
Jeffrey R. Deschamps 5
Author
Martin W. Brechbiel 1
Author
1
Radiation Oncology Branch - Radioimmune & Inorganic Chemistry Section [Bethesda, MD, USA] (9000 Rockville Pike, Bethesda, MD 20892. - United States)
- NIH - National Institutes of Health [Bethesda] (9000 Rockville Pike, Bethesda, Maryland 20892 - United States)
- NCI-NIH - National Cancer Institute [Bethesda] (BG 9609 MSC 9760, 9609 Medical Center Drive, Bethesda, MD 20892-9760 - United States)
- NIH - National Institutes of Health [Bethesda] (9000 Rockville Pike, Bethesda, Maryland 20892 - United States)
2
Division of Computational Bioscience - Center for Molecular Modeling [Bethesda, MD, USA] (Center for Information Technology - 9000 Rockville Pike, Bethesda, MD 20892. - United States)
- NIH - National Institutes of Health [Bethesda] (9000 Rockville Pike, Bethesda, Maryland 20892 - United States)
3
CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique (6 Av Victor Le Gorgeu - BP 809 29285 BREST CEDEX - France)
- IBSAM - Institut Brestois Santé Agro Matière (Université de Brest- UBO
29238 Brest - France)
- UBO - Université de Brest (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
- CNRS - Centre National de la Recherche Scientifique : UMR6521 (France)
- INC - Institut de Chimie du CNRS (3 Rue Michel-Ange 75 016 Paris - France)
- UBO - Université de Brest (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
4
Positron Emission Tomography Department (Positron Emission Tomography Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, USA - United States)
- NIH - National Institutes of Health [Bethesda] (9000 Rockville Pike, Bethesda, Maryland 20892 - United States)
5
Center for Bio/Molecular Science and Engineering (Center for Bio/Molecular Science and Engineering, Code 6900, U.S. Naval Research Laboratory, USA - United States)
Abstract : Single crystal X-ray diffraction shows that Zr(IV) forms an octa-coordinated complex with 4 bidentate hydroxamates whose solution structures were investigated by utilizing density functional theory at the level of B3LYP/DGDZVP. Stability constants obtained by potentiometry were in accordance with the tendency observed when radiolabeling with 89Zr.
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Journal articles
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https://hal.univ-brest.fr/hal-01555852
Contributor : Nicolas Renard Connect in order to contact the contributor
Submitted on : Tuesday, July 4, 2017 - 3:04:20 PM
Last modification on : Monday, October 11, 2021 - 2:22:08 PM
Contributor : Nicolas Renard Connect in order to contact the contributor
Submitted on : Tuesday, July 4, 2017 - 3:04:20 PM
Last modification on : Monday, October 11, 2021 - 2:22:08 PM
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- HAL Id : hal-01555852, version 1
- DOI : 10.1039/C2CC37549D
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UNIV-BREST | CNRS | CEMCA-BREST | INC-CNRS | IBSAM
Citation
François Guérard, Yong-Sok Lee, Raphaël Tripier, Lawrence P. Szajek, Jeffrey R. Deschamps, et al.. Investigation of Zr( iv ) and 89 Zr( iv ) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging. Chemical Communications, Royal Society of Chemistry, 2013, 49 (10), pp.1002 - 1004. ⟨10.1039/C2CC37549D⟩. ⟨hal-01555852⟩
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