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Impairment of quality of life in patients with antiphospholipid syndrome

Abstract : Health-related quality of life (HRQoL) has not been fully explored in antiphospholipid syndrome (APS); therefore, we compared HRQoL between APS patients and the general population and assessed the impact of thromboembolic history. HRQoL was measured in a multicentre cohort study by the Medical Outcomes Study Short-Form 36 (MOS-SF-36) questionnaire. HRQoL scores were compared to the French general population norms. Factors significantly associated with an impaired HRQoL were identified. A total of 115 patients with aPL and/or systemic lupus erythematosus (SLE) were included (mean age 42.7 ± 14.1 years old, 86 women). In 53 patients APS was diagnosed. Compared to general population norms, patients with APS had an impaired HRQoL. SLE-associated APS patients had the worst HRQoL scores (physical component summary (PCS)=40.8 ± 10.6; mental component summary (MCS)=40.6 ± 16.5) in comparison with SLE or aPL patients without thromboembolic history. In APS patients, history of arterial thrombosis significantly impaired HRQoL (PCS score: 42.2 ± 9.4 vs 49.2 ± 8.5; MCS score: 33.9 ± 13.7 vs 44.6 ± 10.3). Compared to the general population, APS patients experienced a lower HRQoL. In these patients, a history of arterial thrombosis significantly impaired HRQoL. Therefore, measurements of HRQoL should be included in APS patient management to assess the burden of the disease from a patient's perspective and to provide patients with the support they need.
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Contributor : Ghislaine Calvez Connect in order to contact the contributor
Submitted on : Friday, February 19, 2016 - 3:56:43 PM
Last modification on : Thursday, March 31, 2022 - 11:00:02 AM



S Zuily, A-C Rat, V Regnault, P Kaminsky, P Mismetti, et al.. Impairment of quality of life in patients with antiphospholipid syndrome. Lupus, 2015, 24 (11), pp.1161-8. ⟨10.1177/0961203315580871⟩. ⟨hal-01276576⟩



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