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Prevalence of antiphospholipid antibodies in psychiatric patients users and non-users of antipsychotics.

Abstract : Past reports have suggested that antiphospholipid (aPL) antibodies may emerge as a response to antipsychotics treatment, as a high prevalence of aPL antibodies in antipsychotics users has been observed. However, no control group of non-medicated psychiatric patients was included in these reports. In a cross sectional study we determined the prevalence of aPL antibodies in 333 psychiatric inpatients. We compared the proportions of positive aPL antibodytests between users and non-users of antipsychotics with adjustments for potential confounders. The proportion of antipsychotics users carrying at least one aPL antibody ranged from 10*8% to 27*0% compared with 6*8% to 27*2% in non-users (P = 0*24, P = 0*24) depending on the method of detection of lupus anticoagulant (LA). The prevalence of LA detected by dilute Russell viper venom time or partial thromboplastin time-LA was not different between antipsychotics users and non-users (8*1% vs. 5*4%, P = 0*53 and 18*4% vs. 18*2%, P = 0*22), as well as the prevalence of IgM and IgG anti-β2-glycoprotein-I antibodies, IgM and IgG anti-cardiolipin antibodies(3*8% vs. 2*0%, P = 0*75, 0*0% vs. 0*0%, P = not applicable, 1*1 vs. 1*4%, P = 0*91, 2*7% vs. 3*4%, P = 0*71). In conclusion, aPL antibodies were frequently found in patients with psychiatric diseases and no significant increase in the prevalence of aPL antibodies was observed in antipsychotics users.
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https://hal.univ-brest.fr/hal-00936011
Contributor : Ghislaine Calvez <>
Submitted on : Friday, January 24, 2014 - 12:22:24 PM
Last modification on : Friday, March 27, 2020 - 2:25:21 AM

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Aurélien Delluc, Aurélie Rousseau, Mickael Le Galudec, Olivier Canceil, Barry Woodhams, et al.. Prevalence of antiphospholipid antibodies in psychiatric patients users and non-users of antipsychotics.. British Journal of Haematology, Wiley, 2014, 164 (2), pp.272-9. ⟨10.1111/bjh.12627⟩. ⟨hal-00936011⟩

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