Oxidative stress in breath-hold divers after repetitive dives. - Université de Bretagne Occidentale Access content directly
Journal Articles Diving Hyperb Med Year : 2013

Oxidative stress in breath-hold divers after repetitive dives.

Sigrid Theunissen
  • Function : Author
  • PersonId : 767095
  • IdRef : 180417371
Nicola Sponsiello
  • Function : Author
Miroslav Rozloznik
  • Function : Author
Peter Germonpré
Danilo Cialoni
  • Function : Author

Abstract

INTRODUCTION: Hyperoxia causes oxidative stress. Breath-hold diving is associated with transient hyperoxia followed by hypoxia and a build-up of carbon dioxide (CO₂), chest-wall compression and significant haemodynamic changes. This study analyses variations in plasma oxidative stress markers after a series of repetitive breath-hold dives. METHODS: Thirteen breath-hold divers were asked to perform repetitive breath-hold dives to 20 metres' depth to a cumulative breath-hold time of approximately 20 minutes over an hour in the open sea. Plasma nitric oxide (NO), peroxinitrites (ONOO⁻) and thiols (R-SH) were measured before and after the dive sequence. RESULTS: Circulating NO significantly increased after successive breath-hold dives (169.1 ± 58.26% of pre-dive values; P = 0.0002). Peroxinitrites doubled after the dives (207.2 ± 78.31% of pre-dive values; P = 0.0012). Thiols were significantly reduced (69.88 ± 19.23% of pre-dive values; P = 0.0002). CONCLUSION: NO may be produced by physical effort during breath-hold diving. Physical exercise, the transient hyperoxia followed by hypoxia and CO₂ accumulation would all contribute to the increased levels of superoxide anions (O₂²⁻). Since interaction of O₂²⁻ with NO forms ONOO⁻, this reaction is favoured and the production of thiol groups is reduced. Oxidative stress is, thus, present in breath-hold diving.
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  • HAL Id : hal-00842024 , version 1
  • PUBMED : 23813458

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Sigrid Theunissen, Nicola Sponsiello, Miroslav Rozloznik, Peter Germonpré, François Guerrero, et al.. Oxidative stress in breath-hold divers after repetitive dives.. Diving Hyperb Med, 2013, 43 (2), pp.63-6. ⟨hal-00842024⟩
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