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Journal articles
Homozygous FCGR3A-158F mutation is associated with delayed B-cell depletion following rituximab but with preserved efficacy in a patient with refractory lupus nephri
Abstract : Rituximab (RTX), an anti-CD20 monoclonal antibody, has shown promising results in a small group of systemic lupus erythematosus (SLE) patients treated for lupus nephritis (LN). However, such observations were not confirmed in the double-blind LUNAR study. Accordingly, the factors associated with the clinical response remain to be characterized. We report the case of a young woman with known LN successfully re-treated with RTX and steroids and homozygous for the low-affinity FCG3RA 158F genotype. Although B-cell depletion was delayed, complete remission with anti-DNA antibody negativity and proteinuria normalization were maintained for 5 years. The implications for disease pathogenesis and clinical monitoring are discussed.
Cited literature [2 references]
https://hal.univ-brest.fr/hal-00827682
Contributor : Geneviève Michel <>
Submitted on : Thursday, February 4, 2016 - 8:26:41 AM
Last modification on : Thursday, April 19, 2018 - 4:40:04 PM
Long-term archiving on: : Saturday, November 12, 2016 - 7:47:49 AM
Contributor : Geneviève Michel <>
Submitted on : Thursday, February 4, 2016 - 8:26:41 AM
Last modification on : Thursday, April 19, 2018 - 4:40:04 PM
Long-term archiving on: : Saturday, November 12, 2016 - 7:47:49 AM
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Clin Kidney J-2012-Seret-ckj_s...
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