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A case for the graft-versus-host disease as a model for B cell-mediated autoimmunity.

Isabelle Segalen 1 Tinhinane Fali 1 Jacques-Olivier Pers 1 Yann Le Meur 1, 2 Pierre Youinou 1, 3 Séverine Loisel 1
1 EA2216 - Immunologie et Pathologie
2 PIST - Pharmacologie des Immunosuppresseurs et de la Transplantation
3 Laboratoire d'Immunologie et Immunothérapie
Abstract : Following allogenic hematopoietic stem cell transplantation (HSCT), patients with autoimmune disease or hematopoietic malignancy may develop acute or chronic graft-versus-host (GvH) disease. B lymphocytes, from the recipient as well as from the donor, have recently been implicated in the pathogenesis of such disturbances. Their deleterious effects are accounted for by other tasks B lymphocytes accomplish than the antibody production. We highlight herein some recent observations in the context of B cells in the GvH disease.
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https://hal.univ-brest.fr/hal-00771281
Contributor : Geneviève Michel Connect in order to contact the contributor
Submitted on : Tuesday, January 8, 2013 - 12:40:59 PM
Last modification on : Tuesday, March 29, 2022 - 4:07:12 AM

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UNIV-BREST | UNILIM | UMR-S850 | IMMUNO | GEIST | CNRS | IPPRITT | OMEGAHEALTH

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Isabelle Segalen, Tinhinane Fali, Jacques-Olivier Pers, Yann Le Meur, Pierre Youinou, et al.. A case for the graft-versus-host disease as a model for B cell-mediated autoimmunity.. Autoimmunity Reviews, Elsevier, 2011, 10 (4), pp.218-21. ⟨10.1016/j.autrev.2010.10.005⟩. ⟨hal-00771281⟩

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