A case for the graft-versus-host disease as a model for B cell-mediated autoimmunity.

Isabelle Segalen 1 Tinhinane Fali 1 Jacques-Olivier Pers 1 Yann Le Meur 1, 2 Pierre Youinou 1, 3 Séverine Loisel 1
1 EA2216 - Immunologie et Pathologie
2 PIST - Pharmacologie des Immunosuppresseurs et de la Transplantation
3 Laboratoire d'Immunologie et Immunothérapie
Abstract : Following allogenic hematopoietic stem cell transplantation (HSCT), patients with autoimmune disease or hematopoietic malignancy may develop acute or chronic graft-versus-host (GvH) disease. B lymphocytes, from the recipient as well as from the donor, have recently been implicated in the pathogenesis of such disturbances. Their deleterious effects are accounted for by other tasks B lymphocytes accomplish than the antibody production. We highlight herein some recent observations in the context of B cells in the GvH disease.
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Autoimmunity Reviews, Elsevier, 2011, 10 (4), pp.218-21. 〈10.1016/j.autrev.2010.10.005〉
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Contributeur : Geneviève Michel <>
Soumis le : mardi 8 janvier 2013 - 12:40:59
Dernière modification le : vendredi 16 février 2018 - 15:24:59

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UNIV-BREST | UMR-S850 | UNILIM | IMMUNO | GEIST | IPPRITT

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Isabelle Segalen, Tinhinane Fali, Jacques-Olivier Pers, Yann Le Meur, Pierre Youinou, et al.. A case for the graft-versus-host disease as a model for B cell-mediated autoimmunity.. Autoimmunity Reviews, Elsevier, 2011, 10 (4), pp.218-21. 〈10.1016/j.autrev.2010.10.005〉. 〈hal-00771281〉

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