Abstract : Following allogenic hematopoietic stem cell transplantation (HSCT), patients with autoimmune disease or hematopoietic malignancy may develop acute or chronic graft-versus-host (GvH) disease. B lymphocytes, from the recipient as well as from the donor, have recently been implicated in the pathogenesis of such disturbances. Their deleterious effects are accounted for by other tasks B lymphocytes accomplish than the antibody production. We highlight herein some recent observations in the context of B cells in the GvH disease.
http://hal.univ-brest.fr/hal-00771281
Contributeur : Geneviève Michel
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Soumis le : mardi 8 janvier 2013 - 12:40:59
Dernière modification le : vendredi 16 février 2018 - 15:24:59
Isabelle Segalen, Tinhinane Fali, Jacques-Olivier Pers, Yann Le Meur, Pierre Youinou, et al.. A case for the graft-versus-host disease as a model for B cell-mediated autoimmunity.. Autoimmunity Reviews, Elsevier, 2011, 10 (4), pp.218-21. 〈10.1016/j.autrev.2010.10.005〉. 〈hal-00771281〉
