A case for the graft-versus-host disease as a model for B cell-mediated autoimmunity. - Université de Bretagne Occidentale Access content directly
Journal Articles Autoimmunity Reviews Year : 2011

A case for the graft-versus-host disease as a model for B cell-mediated autoimmunity.

Abstract

Following allogenic hematopoietic stem cell transplantation (HSCT), patients with autoimmune disease or hematopoietic malignancy may develop acute or chronic graft-versus-host (GvH) disease. B lymphocytes, from the recipient as well as from the donor, have recently been implicated in the pathogenesis of such disturbances. Their deleterious effects are accounted for by other tasks B lymphocytes accomplish than the antibody production. We highlight herein some recent observations in the context of B cells in the GvH disease.

Domains

Immunology

Dates and versions

hal-00771281 , version 1 (08-01-2013)

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Cite

Isabelle Segalen, Tinhinane Fali, Jacques-Olivier Pers, Yann Le Meur, Pierre Youinou, et al.. A case for the graft-versus-host disease as a model for B cell-mediated autoimmunity.. Autoimmunity Reviews, 2011, 10 (4), pp.218-21. ⟨10.1016/j.autrev.2010.10.005⟩. ⟨hal-00771281⟩
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