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Regulatory B cells play a key role in immune system balance.

Abstract : Regulatory B cells (Bregs) may act earlier than regulatory T cells (Tregs) and may play as important a role in autoimmune and allergic diseases. Obstacles to the investigation of Bregs are the same as those encountered for Tregs: the regulatory effects are short-lived in some cases, there is no consistent phenotype (C5 expression is neither indispensable nor sufficient), differences exist across species (e.g., between humans and mice), and there are a number of suppression modalities (IL-10, TGF-beta, expression of proapoptotic membrane molecules) that vary across Breg subtypes. The Breg subtypes may be homologous to the Treg subtypes (Br1 cells expressing IL-10, Br3 cells expressing TGF-beta, and B-Foxp3 cells), although the Br1 subtype seems to predominate. Nevertheless, differences with Treg cells may exist: Breg activation may chiefly involve the toll-like receptors rather than the antigen receptor; and Bregs act earlier, facilitating the recruitment of Tregs then disappearing once the Tregs become operational. Bregs make a major contribution to autoimmune disorders associated with several forms of immune deficiency, as well as to the absence of transplant rejection when there is a strong B cell response. Breg deficiencies have been reported in lupus, and the disappointing effects in this disease of treatments designed to inhibit the B cell response may be related to further Breg impairment. In several animal models, Breg stimulation is effective in correcting a variety of autoimmune disorders, most notably those initiated in the mucous membranes. Research into the interactions between the gut microbiota and Bregs holds considerable promise.
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Contributor : Geneviève Michel Connect in order to contact the contributor
Submitted on : Tuesday, January 8, 2013 - 8:59:48 AM
Last modification on : Friday, August 5, 2022 - 8:44:49 AM



Jean-Marie Berthelot, Jamin Christophe, Kahina Amrouche, Benoit Le Goff, Yves Maugars, et al.. Regulatory B cells play a key role in immune system balance.. Joint Bone Spine, 2012, epub ahead of print. ⟨10.1016/j.jbspin.2012.04.010⟩. ⟨hal-00771025⟩



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