Altered patterns of epigenetic changes in systemic lupus erythematosus and auto-antibody production: is there a link? - Université de Bretagne Occidentale Access content directly
Journal Articles Journal of Autoimmunity Year : 2012

Altered patterns of epigenetic changes in systemic lupus erythematosus and auto-antibody production: is there a link?

Abstract

The prominent feature of immunological defects in systemic lupus erythematosus (SLE) is the production of autoantibodies (auto-Abs) to nuclear antigens including DNA, histones and RNP. In addition, there is growing evidence that epigenetic changes play a key role in the pathogenesis of SLE. Autoreactive CD4(+) T cells and B cells in patients with SLE have evidence of altered patterns of DNA methylation as well as post-translational modifications of histones and ribonucleoproteins (RNP). A key question that has emerged from these two characteristic features of SLE is whether the two processes are linked. New data provide support for such a link. For example, there is evidence that hypomethylated DNA is immunogenic, that anti-histone auto-Abs in patients with SLE bind epigenetic-sensitive hot spots and that epigenetically-modified RNP-derived peptides can modulate lupus disease. All in all, the available evidence indicates that a better understanding of dysregulation in epigenetics in SLE may offer opportunities to develop new biomarkers and novel therapeutic strategies.

Domains

Immunology

Dates and versions

hal-00770817 , version 1 (07-01-2013)

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Yosra Thabet, Felipe Cañas, Ibtissem Ghedira, Pierre Youinou, Rizgar A Mageed, et al.. Altered patterns of epigenetic changes in systemic lupus erythematosus and auto-antibody production: is there a link?. Journal of Autoimmunity, 2012, 39 (3), pp.154-60. ⟨10.1016/j.jaut.2012.05.015⟩. ⟨hal-00770817⟩

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