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Altered patterns of epigenetic changes in systemic lupus erythematosus and auto-antibody production: is there a link?

Abstract : The prominent feature of immunological defects in systemic lupus erythematosus (SLE) is the production of autoantibodies (auto-Abs) to nuclear antigens including DNA, histones and RNP. In addition, there is growing evidence that epigenetic changes play a key role in the pathogenesis of SLE. Autoreactive CD4(+) T cells and B cells in patients with SLE have evidence of altered patterns of DNA methylation as well as post-translational modifications of histones and ribonucleoproteins (RNP). A key question that has emerged from these two characteristic features of SLE is whether the two processes are linked. New data provide support for such a link. For example, there is evidence that hypomethylated DNA is immunogenic, that anti-histone auto-Abs in patients with SLE bind epigenetic-sensitive hot spots and that epigenetically-modified RNP-derived peptides can modulate lupus disease. All in all, the available evidence indicates that a better understanding of dysregulation in epigenetics in SLE may offer opportunities to develop new biomarkers and novel therapeutic strategies.
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https://hal.univ-brest.fr/hal-00770817
Contributor : Geneviève Michel Connect in order to contact the contributor
Submitted on : Monday, January 7, 2013 - 3:24:26 PM
Last modification on : Monday, October 11, 2021 - 2:23:08 PM

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Yosra Thabet, Felipe Cañas, Ibtissem Ghedira, Pierre Youinou, Rizgar A Mageed, et al.. Altered patterns of epigenetic changes in systemic lupus erythematosus and auto-antibody production: is there a link?. Journal of Autoimmunity, Elsevier, 2012, 39 (3), pp.154-60. ⟨10.1016/j.jaut.2012.05.015⟩. ⟨hal-00770817⟩

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