Altered patterns of epigenetic changes in systemic lupus erythematosus and auto-antibody production: is there a link?

Yosra Thabet 1 Felipe Cañas 1 Ibtissem Ghedira 2 Pierre Youinou 1, 3 Rizgar A Mageed 4 Yves Renaudineau 1, 3
1 EA2216 - Immunologie et Pathologie
2 Autoimmunity and Allergy Research Unit
3 Laboratoire d'Immunologie et Immunothérapie
4 William Harvey Research Institute, Barts and the London Medical School
Abstract : The prominent feature of immunological defects in systemic lupus erythematosus (SLE) is the production of autoantibodies (auto-Abs) to nuclear antigens including DNA, histones and RNP. In addition, there is growing evidence that epigenetic changes play a key role in the pathogenesis of SLE. Autoreactive CD4(+) T cells and B cells in patients with SLE have evidence of altered patterns of DNA methylation as well as post-translational modifications of histones and ribonucleoproteins (RNP). A key question that has emerged from these two characteristic features of SLE is whether the two processes are linked. New data provide support for such a link. For example, there is evidence that hypomethylated DNA is immunogenic, that anti-histone auto-Abs in patients with SLE bind epigenetic-sensitive hot spots and that epigenetically-modified RNP-derived peptides can modulate lupus disease. All in all, the available evidence indicates that a better understanding of dysregulation in epigenetics in SLE may offer opportunities to develop new biomarkers and novel therapeutic strategies.
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Article dans une revue
Journal of Autoimmunity, Elsevier, 2012, 39 (3), pp.154-60. 〈10.1016/j.jaut.2012.05.015〉
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http://hal.univ-brest.fr/hal-00770817
Contributeur : Geneviève Michel <>
Soumis le : lundi 7 janvier 2013 - 15:24:26
Dernière modification le : mercredi 29 novembre 2017 - 14:53:51

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Yosra Thabet, Felipe Cañas, Ibtissem Ghedira, Pierre Youinou, Rizgar A Mageed, et al.. Altered patterns of epigenetic changes in systemic lupus erythematosus and auto-antibody production: is there a link?. Journal of Autoimmunity, Elsevier, 2012, 39 (3), pp.154-60. 〈10.1016/j.jaut.2012.05.015〉. 〈hal-00770817〉

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