Are women with severely symptomatic brugada syndrome different from men? - Université de Bretagne Occidentale Access content directly
Journal Articles Journal of Cardiovascular Electrophysiology Year : 2008

Are women with severely symptomatic brugada syndrome different from men?

Paola Meregalli
  • Function : Author
Christian Veltmann
  • Function : Author
Michael E Field
  • Function : Author
Aude Solnon
  • Function : Author
Sélim Abbey
  • Function : Author
Hanno L Tan
  • Function : Author
Christian Wolpert
  • Function : Author
Gilles Lande
  • Function : Author
Valérie Bertault
  • Function : Author
Dominique Babuty
  • Function : Author
Serge Boveda
Philippe Maury
Jacques Clémenty
  • Function : Author
Martin Borggrefe
  • Function : Author


UNLABELLED: Women with Brugada Syndrome. INTRODUCTION: Spontaneous type-1 ECG has been recognized as a risk factor for sudden cardiac death (SCD) in Brugada syndrome (BrS), but studied populations predominantly consisted of men. We sought to investigate whether a spontaneous type-1 ECG pattern was also associated in women with severely symptomatic BrS. Other known risk factors were also examined for gender specificity. METHODS: Patients with severely symptomatic BrS, defined as resuscitated SCD and/or appropriate implantable cardioverter-defibrillator (ICD) shock, were included from 11 European centers. Clinical data, investigation of family history, 12-lead ECG, and results of electrophysiological study (EPS) were collected. The average follow-up was 4 +/- 3 years. RESULTS: Fifty-eight patients fulfilled the inclusion criteria (mean age 47 +/- 11 years, 8 women). Thirty-six men (72%) but only two women (25%) had a spontaneous type-1 ECG at baseline (P = 0.02). Maximal ST elevation before or after drug challenge was 3.7 +/- 1.3 mm in men versus 2.4 +/- 0.7 mm in women (P = 0.007). The proportion of patients with a family history of SCD or an SCN5A mutation was not significantly different between both groups. Of those patients with high-risk BrS who underwent EPS, 76%(12/25) of men and 50%(2/4) of women had a positive study. CONCLUSION: In contrast to men, most women with BrS and resuscitated SCD or appropriate ICD shock do not have a spontaneous type-1 ECG pattern. In addition, the degree of ST elevation is less pronounced in women than men. While women represent a lower-risk group overall, risk factors established from a predominantly male population may not be helpful in identifying high-risk females.

Dates and versions

hal-00750427 , version 1 (09-11-2012)



Frédéric Sacher, Paola Meregalli, Christian Veltmann, Michael E Field, Aude Solnon, et al.. Are women with severely symptomatic brugada syndrome different from men?. Journal of Cardiovascular Electrophysiology, 2008, 19 (11), pp.1181-5. ⟨10.1111/j.1540-8167.2008.01223.x⟩. ⟨hal-00750427⟩
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