Materno-fetal transmission of human coronaviruses: a prospective pilot study. - Université de Bretagne Occidentale Access content directly
Journal Articles European Journal of Clinical Microbiology and Infectious Diseases Year : 2008

Materno-fetal transmission of human coronaviruses: a prospective pilot study.

Abstract

This prospective pilot study investigates the possibility of materno-fetal transmission of human coronaviruses (HCoV) responsible for cases of neonatal infection. This vertical transmission was studied with 159 samples from mother-child couples: maternal vaginal (MV) and respiratory (MR) samples during labor; and newborn gastric sample (NG) with detection of HCoV (229E, OC-43, NL-63, HKU1) via real time RT PCR. HCoV was detected in 12 samples (229E: 11; HKU1: 1) from seven mother-child couples. For three couples, only MR tested positive (cases 1-3). For two other couples all three samples (MV, MR and NG) tested positive (cases 4 and 5). For case 6, only MV and NG tested positive. In case 7, only MV was positive. Possible vertical transmission of HCoV was hypothesized in this pilot study and requires further investigation on a larger scale.

Dates and versions

hal-00749719 , version 1 (08-11-2012)

Identifiers

Cite

Arnaud Gagneur, E. Dirson, S. Audebert, S. Vallet, M. C. Legrand-Quillien, et al.. Materno-fetal transmission of human coronaviruses: a prospective pilot study.. European Journal of Clinical Microbiology and Infectious Diseases, 2008, 27 (9), pp.863-6. ⟨10.1007/s10096-008-0505-7⟩. ⟨hal-00749719⟩
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