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Low molecular weight heparin administered once versus twice daily in patients with venous thromboembolism: a meta-analysis.

Abstract : BACKGROUND: Low molecular weight heparin is as effective and safe as unfractionated heparin for treatment of acute venous thromboembolism. It is uncertain whether low molecular weight heparin should be administered once-daily or twice-daily in this setting. METHOD: A meta-analysis of randomized studies which directly compared once- and twice-daily administration of low molecular weight heparin for the treatment of acute venous thromboembolism was performed. A literature search was performed using Advanced Pub Med and the Cochrane library database, and abstracts from recent meetings were reviewed. Two investigators extracted data independently. RESULTS: Five studies, involving 1522 patients, were eligible. There were no statistically significant differences in the frequencies of symptomatic (odds ratio, 0.85 in favor of once-daily therapy at three months, p = 0.6), and asymptomatic, recurrent venous thromboembolism, total and major bleeds (odds ratio, 1.16 in favor of twice-daily therapy at 10 days, p = 0.8); and death, at 10 days, as well as at three months of follow-up. CONCLUSION: Once-daily low molecular weight heparin appears to be as effective and safe as twice-daily administration for the acute treatment of venous thromboembolism. However, there is inadequate data from studies that directly compared once-daily and twice-daily administration to be able to exclude the possibility of a higher frequency of fatal bleeding with once-daily therapy.
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Contributor : Ghislaine Calvez Connect in order to contact the contributor
Submitted on : Wednesday, August 1, 2012 - 1:03:33 PM
Last modification on : Thursday, March 31, 2022 - 11:00:02 AM


  • HAL Id : hal-00722338, version 1
  • PUBMED : 11686355



Francis Couturaud, J. A. Julian, Clive Kearon. Low molecular weight heparin administered once versus twice daily in patients with venous thromboembolism: a meta-analysis.. Thrombosis and Haemostasis, 2001, 86 (4), pp.980-4. ⟨hal-00722338⟩



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