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Is APC resistance a risk factor for venous thromboembolism in patients over 70 years?

Abstract : Activated protein C (APC) resistance is the most common risk factor for venous thromboembolism (VTE). Previous studies mostly analysed patients under 70 years and reported a four- to sevenfold increased risk. This case-control study included consecutive patients referred for a clinical suspicion VTE to our medical unit: 621 patients with a well-documented diagnosis (cases) and 406 patients for which the diagnosis was ruled out and who had no personal history of VTE (controls). APC resistance related to factor V Leiden was defined by either a positive DNA analysis or a positive STA(R) Staclot APC-R assay. Under 70 years, APC resistance was associated with a threefold increased risk of VTE (odds ratio 3.2, 95% CI, 1.7 to 6.0), whereas in patients over 70 years, it appeared to be no longer a strong risk factor (odds ratio 0.8, 95% CI, 0.4 to 1.7). Age appeared as an effect-measure modifier with a significant interaction (p = 0.005). Our data suggest that APC resistance is not a risk factor for VTE in elderly.
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https://hal.univ-brest.fr/hal-00722284
Contributor : Ghislaine Calvez <>
Submitted on : Wednesday, August 1, 2012 - 10:57:03 AM
Last modification on : Wednesday, October 14, 2020 - 4:07:53 AM

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Emmanuel Oger, Karine Lacut, Grégoire Le Gal, Patrick van Dreden, Luc Bressollette, et al.. Is APC resistance a risk factor for venous thromboembolism in patients over 70 years?. Thrombosis and Haemostasis, Schattauer, 2002, 88 (4), pp.587-91. ⟨10.1267/th02100587⟩. ⟨hal-00722284⟩

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