Differential effects of oral and transdermal postmenopausal estrogen replacement therapies on C-reactive protein. - Université de Bretagne Occidentale
Journal Articles Thrombosis and Haemostasis Year : 2003

Differential effects of oral and transdermal postmenopausal estrogen replacement therapies on C-reactive protein.

Abstract

C-reactive protein (CRP) is one of the main independent predictors of cardiovascular events. Oral post-menopausal estrogen replacement therapy (ERT) increases CRP levels, but the effect of transdermal ERT is not well documented. CRP, interleukine-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) levels were evaluated in a randomised study of 196 healthy postmenopausal women, who were allocated to receive continuous oral estradiol-1beta, (n=63) or transdermal estradiol-1beta, (n=68) both combined with micronised progesterone, or place-bo (n=65). Oral estrogen increased CRP levels compared with both placebo (p=0.010) and transdermal estrogen (p=0.004) at 6 months. There was no significant effect of transdermal estrogen on CRP levels compared with placebo (p=0.997). No significant difference was found in the median changes for IL-6 and TNF-alpha between the three treatment groups. In conclusion, transdermal estrogen has no significant effect on CRP levels at 6 months, but CRP concentrations increased significantly with oral estrogen although no changes in cytokine levels were detected. The clinical relevance of these effects remains to be determined.
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hal-00722269 , version 1 (01-08-2012)

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Karine Lacut, Emmanuel Oger, Grégoire Le Gal, Marie-Thérèse Blouch, Jean-François Abgrall, et al.. Differential effects of oral and transdermal postmenopausal estrogen replacement therapies on C-reactive protein.. Thrombosis and Haemostasis, 2003, 90 (1), pp.124-31. ⟨10.1267/THRO03010124⟩. ⟨hal-00722269⟩
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