Venous thromboembolism in patients with pancreatic cancer: implications of circulating tissue factor. - Université de Bretagne Occidentale
Journal Articles Blood Coagulation & Fibrinolysis Year : 2011

Venous thromboembolism in patients with pancreatic cancer: implications of circulating tissue factor.

Abstract

Among cancers, pancreatic cancer is known to be associated with a higher incidence of venous thromboembolism (VTE). The aim of the study was to determine the implication of circulating tissue factor (TF) in VTE related to active pancreatic cancer. One hundred and sixty-four consecutive patients who participated to the Etude des Determinants et Interactions de la Thrombose veineuse (EDITH) study between January 2005 and August 2007 for symptomatic VTE related to active pancreatic cancer (n = 8), active cancer of other location (n = 42) or classified as unprovoked (n = 114) were included. TF activity (TFa) was measured in a one-stage kinetic chromogenic method. There were no differences of median TFa levels between patients with VTE related to cancer of other type than pancreas [2.01 pmol/l range (0.05-43.92)] and patients with unprovoked VTE [1.78 pmol/l (range 0.05-63.72), P = 0.21]. Median TFa levels were higher in patients with VTE related to pancreatic cancer [12.67 pmol/l (range 0.05-112.04)] than in patients with VTE related to cancer of other type [2.01 pmol/l (range 0.05-43.92), P = 0.02]. Higher levels of circulating TFa during the course of pancreatic cancer may explain the higher incidence of VTE associated with this type of cancer.
No file

Dates and versions

hal-00721501 , version 1 (27-07-2012)

Identifiers

Cite

Aurélien Delluc, Aurélie Rousseau, Céline Delluc, Emmanuelle Le Moigne, Grégoire Le Gal, et al.. Venous thromboembolism in patients with pancreatic cancer: implications of circulating tissue factor.. Blood Coagulation & Fibrinolysis, 2011, 22 (4), pp.295-300. ⟨10.1097/MBC.0b013e32834512f4⟩. ⟨hal-00721501⟩
34 View
1 Download

Altmetric

Share

More