Effects of the route of oestrogen administration on IGF-1 and IGFBP-3 in healthy postmenopausal women: results from a randomized placebo-controlled study.

Emmanuel Sonnet 1 Karine Lacut 2 Nathalie Roudaut 1 Dominique Mottier 2 Véronique Kerlan 1, 2 Emmanuel Oger 2
1 CHRU - Endocrino - Service d'Endocrinologie
2 GETBO - Groupe d'Etude de la Thrombose de Bretagne Occidentale
Abstract : OBJECTIVE: Oestrogens can modulate the action or secretion of GH. Previous studies in postmenopausal women have shown a differential effect between transdermal 17beta-oestradiol and oral ethynyl-oestradiol on GH and IGF-1 concentrations. This secondary analysis, based on a large randomized trial, aimed to estimate the effect of the route of administration of 17beta-oestradiol in combined hormone replacement therapy with progesterone on IGF-1 and IGFBP-3 levels. DESIGN: IGF-1 and IGFBP-3 were evaluated in a randomized study of 196 healthy postmenopausal women who were randomly allocated to receive on a continuous basis either 1 mg of 17beta-oestradiol orally combined with a daily intake of 100 mg progesterone (group 1; n = 63), or 50 microg of 17beta-oestradiol transdermally combined with a daily intake of 100 mg progesterone (group 2; n = 68), or triple dummy placebo (group 3; n = 65) over a 6-month period. IGF1 and IGFBP-3 levels were available for 133 women. RESULTS: Oral oestrogen significantly decreased IGF-1 levels compared to placebo (P = 0.04) and transdermal oestrogen (P = 0.004), whereas transdermal oestrogen had no effect on IGF-1 levels compared to placebo (P = 0.56). As regards IGFBP-3, no significant difference was detected between the three groups. CONCLUSIONS: Our data indicate that the route of oestrogen administration can influence IGF-1 levels. IGF-1 concentrations decreased significantly with oral oestrogen, whereas no significant change was observed with transdermal oestrogen at 6 months. The clinical relevance of these differential effects remains to be determined, particularly with regard to the risk for cardiovascular diseases.
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Clinical Endocrinology, Wiley, 2007, 66 (5), pp.626-31. 〈10.1111/j.1365-2265.2007.02783.x〉
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http://hal.univ-brest.fr/hal-00688275
Contributeur : Ghislaine Calvez <>
Soumis le : mardi 17 avril 2012 - 11:26:15
Dernière modification le : mercredi 10 janvier 2018 - 14:42:02

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Emmanuel Sonnet, Karine Lacut, Nathalie Roudaut, Dominique Mottier, Véronique Kerlan, et al.. Effects of the route of oestrogen administration on IGF-1 and IGFBP-3 in healthy postmenopausal women: results from a randomized placebo-controlled study.. Clinical Endocrinology, Wiley, 2007, 66 (5), pp.626-31. 〈10.1111/j.1365-2265.2007.02783.x〉. 〈hal-00688275〉

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