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In vitro inhibition activity of different bacteriocin-producing Escherichia coli against Salmonella strains isolated from clinical cases

Abstract : Aims: To compare in vitro the inhibitory activity of four bacteriocin-producing Escherichia coli to a well-characterized panel of Salmonella strains, recently isolated from clinical cases in Switzerland. Methods and Results: A panel of 68 nontyphoidal Salmonella strains was characterized by pulsed-field gel electrophoresis analysis and susceptibility to antibiotics. The majority of tested strains were genetically different, with 40% resistant to at least one antibiotic. E. coli Mcc24 showed highest in vitro activity against Salmonella (100%, microcin 24), followed by E. coli L1000 (94%, microcin B17), E. coli 53 (49%, colicin H) and E. coli 52 (21%, colicin G) as revealed using a cross-streak activity assay. Conclusions: Escherichia coli Mcc24, a genetically modified organism producing microcin 24, and E. coli L1000, a natural strain isolated from human faeces carrying the mcb-operon for microcin B17-production, were the most effective strains in inhibiting in vitro both antibiotic resistant and sensitive Salmonella isolates. Significance and Impact of the Study: Due to an increasing prevalence of antibiotic resistant Salmonella strains, alternative strategies to fight these foodborne pathogens are needed. E. coli L1000 appears to be a promising candidate in view of developing biotechnological alternatives to antibiotics against Salmonella infections.
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https://hal.univ-brest.fr/hal-00559258
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Submitted on : Tuesday, January 25, 2011 - 11:59:47 AM
Last modification on : Thursday, January 6, 2022 - 11:38:04 AM

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A. Zihler, Gwenaelle Le Blay, T. de Wouters, Christophe Lacroix, C. P. Braegger, et al.. In vitro inhibition activity of different bacteriocin-producing Escherichia coli against Salmonella strains isolated from clinical cases. Letters in Applied Microbiology, Wiley, 2009, 49 (1), pp.31-38. ⟨10.1111/j.1472-765X.2009.02614.x⟩. ⟨hal-00559258⟩

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