Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis - Institut de veille sanitaire Access content directly
Journal Articles European Respiratory Journal Year : 2015

Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis

1 Unibas - Université de Bâle = University of Basel = Basel Universität
2 ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Dr. Aiguader, 88, Barcelona
3 MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London
4 CESP - Centre de recherche en épidémiologie et santé des populations
5 IUF - Leibniz Research Institute for Environmental Medicine [Düsseldorf, Germany]
6 Unit of Epidemiology and Medical Statistics, Dept of Public Health and Community Medicine, University of Verona, Verona
7 MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London
8 Inserm U823, Environmental Epidemiology Applied to Reproduction and Respiratory Health Team, Grenoble Univ. Joseph Fourier, Grenoble
9 MRC Unit for Lifelong Health and Ageing, Research Department of Epidemiology and Public Health, University College, London
10 Division of Pulmonary Medicine, University Hospitals of Geneva, Geneva
11 Universiteit Utrecht / Utrecht University [Utrecht]
12 UNIPV - Università degli Studi di Pavia = University of Pavia
13 Helmholtz Zentrum, München and German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg
14 Helmholtz Zentrum, München and German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg Environmental Science Center, University Augsburg, Augsburg
15 CREAL - Center for Research in Environmental Epidemiology
16 Centre for Environmental Policy, Imperial College London,´
17 Environmental and Occupational Medicine, Dept of Public Health and Clinical Medicine, Umeå University, Umeå
18 InVS, French Institute for Public Health Surveillance, Saint-Maurice
19 Dept of Public Health and Pediatrics, University of Turin, Turin
20 SC Pneumologia CPA ASL 4 Turin, Turin
21 Air Quality and Sustainable Nanotechnology, IUTA Institut für Energie- und Umwelttechnik e.V., Duisburg
22 MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London Dept of Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College London, London
23 nserm U823, Environmental Epidemiology Applied to Reproduction and Respiratory Health Team, Grenoble Univ. Joseph Fourier, Grenoble Pédiatrie, CHU de Grenoble, La Tronche
24 Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain Steering Committee of ESCAPE Work Package 4 on Respiratory Health in Adults
25 MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London Public Health and Primary Care Directorate, Imperial College Healthcare NHS Trust, London, UK Steering Committee of ESCAPE Work Package 4 on Respiratory Health in Adults

Abstract

The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Residential exposure to nitrogen oxides (NO 2 , NO x ) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV 1 ) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis. We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10 μg·m −3 increase in NO 2 exposure was associated with lower levels of FEV 1 (−14.0 mL, 95% CI −25.8 to −2.1) and FVC (−14.9 mL, 95% CI −28.7 to −1.1). An increase of 10 μg·m −3 in PM 10 , but not other PM metrics (PM 2.5 , coarse fraction of PM, PM absorbance), was associated with a lower level of FEV 1 (−44.6 mL, 95% CI −85.4 to −3.8) and FVC (−59.0 mL, 95% CI −112.3 to −5.6). The associations were particularly strong in obese persons. This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe.
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Origin : Publication funded by an institution
licence : CC BY - Attribution

Dates and versions

hal-04314689 , version 1 (29-11-2023)

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Martin Adam, Tamara Schikowski, Anne Elie Carsin, Yutong Cai, Benedicte Jacquemin, et al.. Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis. European Respiratory Journal, 2015, 45 (1), pp.38-50. ⟨10.1183/09031936.00130014⟩. ⟨hal-04314689⟩
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