A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1.

Abstract : To identify genetic susceptibility factors conferring increased risk of venous thrombosis (VT), we conducted a multistage study, following results of a previously published GWAS that failed to detect loci for developing VT. Using a collection of 5862 cases with VT and 7112 healthy controls, we identified the HIVEP1 locus on chromosome 6p24.1 as a susceptibility locus for VT. Indeed, the HIVEP1 rs169713C allele was associated with an increased risk for VT, with an odds ratio of 1.20 (95% confidence interval 1.13-1.27, p = 2.86 x 10(-9)). HIVEP1 codes for a protein that participates in the transcriptional regulation of inflammatory target genes by binding specific DNA sequences in their promoter and enhancer regions. The current results provide the identification of a locus involved in VT susceptibility that lies outside the traditional coagulation/fibrinolysis pathway.
Type de document :
Article dans une revue
American Journal of Human Genetics, Elsevier (Cell Press), 2010, 86 (4), pp.592-5. 〈10.1016/j.ajhg.2010.02.011〉
Liste complète des métadonnées

http://hal.univ-brest.fr/hal-00930143
Contributeur : Ghislaine Calvez <>
Soumis le : mardi 14 janvier 2014 - 13:26:54
Dernière modification le : samedi 20 janvier 2018 - 01:16:42

Identifiants

Citation

Pierre-Emmanuel Morange, Irene Bezemer, Noémie Saut, Lance Bare, Gwenaelle Burgos, et al.. A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1.. American Journal of Human Genetics, Elsevier (Cell Press), 2010, 86 (4), pp.592-5. 〈10.1016/j.ajhg.2010.02.011〉. 〈hal-00930143〉

Partager

Métriques

Consultations de la notice

456