International Ocean Discovery Program (IODP) Expedition 385 focused on the impact of sill emplacement and fluid flow on subsurface biogeochemical processes in organic-rich sediments of the Guaymas Basin. It resulted in the drilling of eight sites with contrasted settings; Sites U1545 and U1546 were drilled in the northern basin and allowed the recovery of a deep sill at Site U1546; Sites U1547 and U1548 were drilled on an active hydrothermal vent called Ringvent; Sites U1549 and U1552 were drilled on the Sonora margin where cold seeps and hydrates were identified; Site U1550 was sampled as a replicate of Deep Sea Drilling Project (DSDP) Leg 64 Site 481 on an axial trough; and Site U1551 was drilled ~29 km southeast of the axial graben and was mainly terrigenous. The quantitative X-ray fluorescence data presented here were measured on squeeze cakes retrieved after squeezing of whole-round core segments for pore water extraction. Major elements (Al, Ca, Cl, Fe, K, Mg, Mn, Na, P, Si, Ti, and S) as well as minor/trace elements (As, Ba, Br, Ce, Co, Cr, Cu, La, Mo, Nb, Ni, Pb, Rb, Sc, Sr, V, Y, Zn, and Zr) are provided in this data report.