Emerging contaminants (CECs) are defined as unregulated or inadequately regulated chemicals. Many of them are used and released continuously into the environment, and may cause chronic toxicity, endocrine disruption in humans and aquatic wildlife. Bacterial degradation is an effective way in removing CECs either through metabolic or enzymatic pathways. High concentrations of CECs (musks; galaxolide (HHCB) and tonalide (AHTN)), UV-filters (Octocrylene (OC) and padimate-O(OD-PABA)) have been previously reported in sediments of a submarine canyon (Capbreton canyon). The bacterial strains belonging to the genus Bacillus sp. (S-1, S-2, S-3, S-5 and S-6) and the genus Rhodococcus sp. (S-4) have been then isolated from the marine sediments enriched with a single CEC and have been tested for their degradation potential against the CEC used for isolation. The aim of this study is to assess the biodegradation of CECs such musks (HHCB and AHTN); UV-Filters (OC and OD PABA); pharmaceuticals (ketoprofen and oxazepam) and pesticide (atrazine) by pure isolated strains related to different genus. The degradation potentials of these compounds were also discussed considering to chemical structure of CECs, phylogeny, and resistance of the strains. The strains were cultivated in MM20 medium and were spiked with a single CEC at 1 mg L-1 for 24 hours incubation for Bacillus sp. and 48 hours for Rhodococcus sp. HHCB, AHTN, OD PABA, OC and Atrazine. The results show that some strains have high degradation potentials against CECs (S-3, S-4 and S-5 strains) whereas others are only able to degrade OC (S-1 and S-2). S-6 was not able to degrade any CEC. For those with high degradation potentials, 5 CECs (HHCB, AHTN, OD-PABA, OC, and ketoprofen) were degraded with different potentials meaning that the degradation extent is CEC-dependent. The results also reveal that atrazine and oxazepam are highly persistent CECs as no degradation by any strain was observed. Moreover, the resistance of the selected two strains belonging to Rhodococcus sp.(S-4) and Bacillus sp.(S-5) was investigated by exposing HHCB, AHTN, OC, OD-PABA, and ketoprofen up to 500 mg L-1. The results showed no toxicity effect for musks and UV-Filters. However, the growth was inhibited when more than 30 and 60 mg L-1 of ketoprofen of S-4 and S-5 were used, respectively. Overall, the experimental results demonstrate that degradation ability of the strains is not linked to toxicity or resistance to CEC.