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Reactivities of cyclam derivatives with metal–amyloid-β

Abstract : Amyloid-β (Aβ) aggregation and metal ion dyshomeostasis are found as the pathological features upon the progress of Alzheimer’s disease. Herein, a series of azamacrocyclic compounds with different properties of Cu(II) and Zn(II) binding and Aβ interaction was rationally selected under criteria based on structural and functional variations on the backbone of Cyclam. Our studies illustrate new examples of azamacrocyclic metal chelators that alter the interactions between metal ions and Aβ and subsequently modify the reactivities of metal–Aβ, with an indication of how the slight structure-property difference can influence such effects of small molecules.
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Submitted on : Thursday, October 8, 2020 - 2:38:51 PM
Last modification on : Wednesday, November 3, 2021 - 7:12:18 AM




Gunhee Kim, Evan Lelong, Juhye Kang, Jong-Min Suh, Nathalie Le Bris, et al.. Reactivities of cyclam derivatives with metal–amyloid-β. Inorganic Chemistry Frontiers, 2020, ⟨10.1039/D0QI00791A⟩. ⟨hal-02961463⟩



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