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Expanding the Scope of Pyclen-Picolinate Lanthanide Chelates to Po-Tential Theranostic Applications
Gwladys Nizou
Chiara Favaretto
1, 2
Francesca Borgna
2
Pascal Grundler
2
Nathalie Saffon-Merceron
3
Carlos Platas-Iglesias
4
Olivier Fougere
5
Olivier Rousseaux
5
Nicholas van der Meulen
2
Cristina Müller
1
Maryline Beyler
6
Raphaël Tripier
6
Gwladys Nizou
Author IdHAL : gwladys-nizou ORCID : https://orcid.org/0000-0001-9829-9327
Chiara Favaretto 1, 2
Author
Francesca Borgna 2
Author
Pascal V. Grundler 2
Author
Nathalie Saffon-Merceron 3
Author IdHAL : saffon ORCID : https://orcid.org/0000-0002-0301-4163
Carlos Platas-Iglesias 4
Author
Olivier Fougere 5
Author
Olivier Rousseaux 5
Author
Nicholas P van der Meulen 2
Author
Cristina Müller 1
Author
Maryline Beyler 6
Author IdHAL : marylinebeyler
Raphaël Tripier 6
Author IdHAL : raphael-tripier ORCID : https://orcid.org/0000-0001-9364-788X
1
ETH Zürich - Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (Hauptgebäude,
Rämistrasse 101,
8092 Zürich - Switzerland)
2
PSI - Paul Scherrer Institute (Villigen PSI, CH5232 Villigen, Suisse - Switzerland)
3
ICT-FR 2599 - Institut de Chimie de Toulouse (118 Route de Narbonne 31062 Toulouse cédex 9 - France)
- IRD - Institut de Recherche pour le Développement (Siège Le Sextant 44, bd de Dunkerque CS 90009 13572 Marseille cedex 02 - France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- CNRS - Centre National de la Recherche Scientifique : FR2599 (France)
- Toulouse INP - Institut National Polytechnique (Toulouse) (France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
4
Departamento de Química Fundamental (Universidade da Coruña, Campus da Zapateira, Rúa da Fraga 10, 15008 A Coruña - Spain)
- Universidade da Coruña (Rúa da Maestranza 9, 15001 A Coruña - Spain)
5
Guerbet Group (Centre de Recherche d’Aulnay-sous-Bois, BP 57400, 95943 Roissy CdG Cedex, France - France)
6
CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique (6 Av Victor Le Gorgeu - BP 809 29285 BREST CEDEX - France)
- UBO - Université de Brest (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
- INC - Institut de Chimie du CNRS (3 Rue Michel-Ange 75 016 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR6521 (France)
- IBSAM - Institut Brestois Santé Agro Matière (Université de Brest- UBO
29238 Brest - France)
- UBO - Université de Brest (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
Résumé : A family of three picolinate pyclen based ligands, previously investigated for the complexation of Y3+ and some lanthanide ions (Gd3+, Eu3+), was studied with 161Tb and 177Lu in view of potential radiotherapeutic applications. The set of six Tb3+ and Lu3+ complexes was synthesized and fully characterized. The coordination properties in the solid state and in solution were thoroughly studied. Potentiometric titrations, corroborated by DFT calculations, showed the very high stability constants of the Tb3+ and Lu3+ complexes, which are associated to remarkable kinetic inertness. A complete radiolabeling study performed with both 161Tb and 177Lu radionuclides, including experiments with regard to the stability with and without scavengers and kinetic inertness using challenging agents, proved that the ligands could reasonably compete with the DOTA analogue. To conclude, the potential of using the same ligand for both radiotherapy and optical imaging was highlighted for the first time.
Document type :
Preprints, Working Papers, ...
Domain :
Complete list of metadatas
https://hal.univ-brest.fr/hal-02891584
Contributor : Nicolas Renard <>
Submitted on : Tuesday, July 7, 2020 - 8:02:56 AM
Last modification on : Wednesday, July 8, 2020 - 3:35:12 AM
Contributor : Nicolas Renard <>
Submitted on : Tuesday, July 7, 2020 - 8:02:56 AM
Last modification on : Wednesday, July 8, 2020 - 3:35:12 AM
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Identifiers
- HAL Id : hal-02891584, version 1
- DOI : 10.26434/chemrxiv.12570950
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UNIV-BREST | CEMCA-BREST | UNIV-TLSE3 | INC-CNRS | IBSAM | CNRS
Citation
Gwladys Nizou, Chiara Favaretto, Francesca Borgna, Pascal Grundler, Nathalie Saffon-Merceron, et al.. Expanding the Scope of Pyclen-Picolinate Lanthanide Chelates to Po-Tential Theranostic Applications. 2020. ⟨hal-02891584⟩
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