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Safety and Efficacy of Immune Checkpoint Inhibitors in Patients with Cancer and Preexisting Autoimmune Disease: A Nationwide Multicenter Cohort Study

Alice Tison 1 Gilles Quéré 1 Laurent Misery 1 Elisa Funck-Brentano 2 François Danlos 3 Emilie Routier 4 Caroline Robert 4 Yohann Loriot 5 Olivier Lambotte 6 Bertille Bonniaud 7 Camille Scalbert 8 Sarah Maanaoui 8 Thierry Lesimple 9 Stéphanie Martinez 10 Marie Marcq 11 Christos Chouaid 12 Catherine Dubos 13 Florence Brunet-Possenti 14 Chloé Stavris 15 Laurent Chiche 15 Nathalie Beneton 16 Sandrine Mansard 17 Florian Guisier 18, 19 Hélène Doubre 20 François Skowron 21 François Aubin 22 Ouidad Zehou 23 Christophe Roge 24 Mickaël Lambert 24 Anne Pham-Ledard 25 Marie Beylot-Barry 25 Rémi Veillon 25 Nora Kramkimel 26 Damien Giacchero 27 Julie De Quatrebarbes 28 Catherine Michel 29 Jean-Bernard Auliac 30 Gilles Gonzales 31 Chantal Decroisette 28 Gwenaelle Le Garff 32 Ioana Carpiuc 33 Hervé Vallerand 34 Emmanuel Nowak 1 Divi Cornec 35, 36 Marie Kostine 25
4 Oncologie dermatologique
Département de médecine oncologique [Gustave Roussy]
5 Oncologie génito-urinaire
Département de médecine oncologique [Gustave Roussy]
19 QuantIF-LITIS - Equipe Quantification en Imagerie Fonctionnelle
LITIS - Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes
Abstract : Immune Checkpoint Inhibitors (ICI) for cancer therapy induce frequent Immune Related Adverse Effects (IRAE). Therefore, most patients with Preexisting Autoimmune Diseases (PAD) have been excluded from clinical trials. This study aims to evaluate the safety and efficacy of ICI in patients with PAD and cancer.
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Journal articles
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https://hal.univ-brest.fr/hal-02267195
Contributor : Geneviève Michel <>
Submitted on : Monday, August 19, 2019 - 10:22:34 AM
Last modification on : Tuesday, June 16, 2020 - 3:25:50 AM

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Alice Tison, Gilles Quéré, Laurent Misery, Elisa Funck-Brentano, François Danlos, et al.. Safety and Efficacy of Immune Checkpoint Inhibitors in Patients with Cancer and Preexisting Autoimmune Disease: A Nationwide Multicenter Cohort Study. Arthritis & rheumatology, Wiley, 2019, ⟨10.1002/art.41068⟩. ⟨hal-02267195⟩

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