Safety and Efficacy of Immune Checkpoint Inhibitors in Patients with Cancer and Preexisting Autoimmune Disease: A Nationwide Multicenter Cohort Study - Université de Bretagne Occidentale Access content directly
Journal Articles Arthritis & rheumatology Year : 2019

Safety and Efficacy of Immune Checkpoint Inhibitors in Patients with Cancer and Preexisting Autoimmune Disease: A Nationwide Multicenter Cohort Study

1 CHRU Brest - Centre Hospitalier Régional Universitaire de Brest
2 AP - HP - Hôpital Ambroise Paré , Assistance Publique - Hôpitaux de Paris
3 IGR - Institut Gustave Roussy
4 Oncologie dermatologique
5 Oncologie génito-urinaire
6 Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
7 CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
8 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
9 CRLCC - CRLCC Eugène Marquis
10 Hopital d'Aix en Provence
11 CHD Vendée - Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon
12 CHI Créteil
13 U955 Inserm - UPEC - IMRB - CEPIA/"Clinical Epidemiology And Ageing : Geriatrics, Primary Care and Public Health" [Créteil]
14 UNICANCER/CRLC - Centre Régional de Lutte contre le Cancer François Baclesse [Caen]
15 AP-HP - Hôpital Bichat - Claude Bernard [Paris]
16 Hôpital Européen [Fondation Ambroise Paré - Marseille]
17 Centre Hospitalier Le Mans (CH Le Mans)
18 CHU Clermont-Ferrand
19 CHU Rouen
20 QuantIF-LITIS - Equipe Quantification en Imagerie Fonctionnelle
21 Hôpital Foch [Suresnes]
22 CH DE VALENCE - Centre Hospitalier de Valence
23 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
24 CHU Henri Mondor [Créteil]
25 CH Morlaix
26 CHU Bordeaux
27 Hôpital Cochin [AP-HP]
28 UNICANCER/CAL - Centre de Lutte contre le Cancer Antoine Lacassagne [Nice]
29 Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois]
30 CH E.Muller Mulhouse - Centre Hospitalier Emile Muller [Mulhouse]
31 CH, Mantes-La-Jolie
32 Centre hospitalier Les Chanaux [Mâcon]
33 Hôpital de St Brieuc
34 Clinique des Cèdres
35 CHU Reims - Hôpital universitaire Robert Debré [Reims]
36 LBAI - Lymphocytes B, Autoimmunité et Immunothérapies
37 CHU - BREST - Rhumato - CHRU Brest - Service de Rhumatologie
Caroline Robert
Thierry Lesimple
Christophe Roge
  • Function : Author
Mickaël Lambert
  • Function : Author
Anne Pham-Ledard
  • Function : Author
Marie Beylot-Barry
Rémi Veillon
  • Function : Author
Jean-Bernard Auliac
Hervé Vallerand
  • Function : Author
  • PersonId : 1010153
Marie Kostine

Abstract

Immune Checkpoint Inhibitors (ICI) for cancer therapy induce frequent Immune Related Adverse Effects (IRAE). Therefore, most patients with Preexisting Autoimmune Diseases (PAD) have been excluded from clinical trials. This study aims to evaluate the safety and efficacy of ICI in patients with PAD and cancer.
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Dates and versions

hal-02267195 , version 1 (19-08-2019)

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Alice Tison, Gilles Quéré, Laurent Misery, Elisa Funck-Brentano, François Danlos, et al.. Safety and Efficacy of Immune Checkpoint Inhibitors in Patients with Cancer and Preexisting Autoimmune Disease: A Nationwide Multicenter Cohort Study. Arthritis & rheumatology, 2019, ⟨10.1002/art.41068⟩. ⟨hal-02267195⟩
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