B. M. Weiss, J. Abadie, P. Verma, R. S. Howard, and W. M. Kuehl, A monoclonal gammopathy precedes multiple myeloma in most patients, Blood, vol.113, pp.5418-5440, 2009.

G. J. Morgan, F. E. Davies, and M. Linet, Myeloma aetiology and epidemiology, Biomed Pharmacother, vol.56, pp.223-257, 2002.

N. Bolli, H. Avet-loiseau, D. C. Wedge, P. Van-loo, L. B. Alexandrov et al., Heterogeneity of genomic evolution and mutational profiles in multiple myeloma, Nat Commun, vol.5, p.2997, 2014.

M. A. Chapman, M. S. Lawrence, J. J. Keats, K. Cibulskis, C. Sougnez et al., Initial genome sequencing and analysis of multiple myeloma, Nature, vol.471, pp.467-72, 2013.

J. G. Lohr, P. Stojanov, S. L. Carter, P. Cruz-gordillo, M. S. Lawrence et al., Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy, Cancer Cell, vol.25, pp.91-101, 2014.

G. J. Morgan, D. C. Johnson, N. Weinhold, H. Goldschmidt, O. Landgren et al., Inherited genetic susceptibility to multiple myeloma, Leukemia, vol.28, pp.518-542, 2014.

M. Went, A. Sud, A. Försti, B. Halvarsson, N. Weinhold et al., Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma, Nat Commun, vol.9, p.3707, 2018.

B. Halvarsson, A. Wihlborg, A. M. Lemonakis, K. Johnsson, E. Niroula et al., Direct evidence for a polygenic etiology in familial multiple myeloma, Blood Adv, vol.1, pp.619-642, 2017.

X. Wei, M. N. Calvo-vidal, S. Chen, G. Wu, M. V. Revuelta et al., Germline mutations in lysine specific demethylase 1 (LSD1/ KDM1A) confer susceptibility to multiple myeloma, Cancer research, 2018.

R. G. Waller, T. M. Darlington, X. Wei, M. J. Madsen, A. Thomas et al., Novel pedigree analysis implicates DNA repair and chromatin remodeling in multiple myeloma risk, PLoS Genet, vol.14, p.1007111, 2018.

S. Weißbach, C. Langer, B. Puppe, T. Nedeva, E. Bach et al., The molecular spectrum and clinical impact of DIS3 mutations in multiple myeloma, Br J Haematol, vol.169, pp.57-70, 2015.

B. A. Walker, K. Mavrommatis, C. P. Wardell, T. C. Ashby, M. Bauer et al., Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma, Blood, vol.132, pp.587-97, 2018.

M. Lionetti, M. Barbieri, K. Todoerti, L. Agnelli, S. Fabris et al., A compendium of DIS3 mutations and associated transcriptional signatures in plasma cell dyscrasias, Oncotarget, 2015.

,

A. Dziembowski, E. Lorentzen, E. Conti, and B. Séraphin, A single subunit, Dis3, is essentially responsible for yeast exosome core activity, Nat Struct Mol Biol, vol.14, pp.15-22, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00167461

S. Robinson, A. Oliver, T. Chevassut, and S. Newbury, The 3' to 5' exoribonuclease DIS3: from structure and mechanisms to biological functions and role in human disease, Biomolecules, vol.5, pp.1515-1554, 2015.

T. Szczepi?ska, K. Kalisiak, R. Tomecki, A. Labno, L. S. Borowski et al., DIS3 shapes the RNA polymerase II transcriptome in humans by degrading a variety of unwanted transcripts, Genome Res, vol.25, pp.1622-1655, 2015.

, 18 ? Philippe Rodon 19 ? Brigitte Kolb 20 ? Borhane Slama 21 ? Philippe Mineur 22 ? Eric Voog 23 ? Catherine Le Bris 24 ? Jean Fontan 25 ? Michel Maigre 26 ? Marie Beaumont 27 ? Isabelle Azais 28 ? Hagay Sobol 29 ? Marguerite Vignon 30 ? Bruno Royer 30 ? Aurore Perrot 31 ? Jean-Gabriel Fuzibet 32 ? Véronique Dorvaux 33 ? Bruno Anglaret 34 ? Pascale Cony-Makhoul 35 ? Christian Berthou 36 ? Florence Desquesnes 37 ? Brigitte Pegourie 38 ? Serge Leyvraz 39 ? Laurent Mosser 40 ? Nicole Frenkiel 41 ? Karine Augeul-Meunier 42 ? Isabelle Leduc 43 ? Cécile Leyronnas 44 ? Laurent Voillat 45 ? Philippe Casassus 46 ? Claire Mathiot 47 ? Nathalie Cheron 48 ? Etienne Paubelle 49 ? Philippe Moreau 50 ? Yves-Jean Bignon 51 ? Bertrand Joly 52 ? Pascal Bourquard 53 ? Denis Caillot 54 ? Hervé Naman 55 ? Sophie Rigaudeau 56 ? Gérald Marit 57 ? Margaret Macro 58 ? Isabelle Lambrecht 59 ? Manuel Cliquennois 60 ? Laure Vincent 61 ? Philippe Helias 62 ? Hervé Avet-Loiseau 63 ? Victor Moreno 64,65 ? Rui Manuel Reis 66,67 ? Judit Varkonyi 68 ? Marcin Kruszewski 69 ? Annette Juul Vangsted 70 ? Artur Jurczyszyn 71 ? Jan Maciej Zaucha 72 ? Juan Sainz 73 ? Malgorzata Krawczyk-Kulis 74 ? Marzena W?tek 75,76 ? Matteo Pelosini 77 ? Elzbieta Iskierka-Ja?d?ewska 78 ? Norbert Grz??ko 79 ? Joaquin Martinez-Lopez 80 ? Andrés Jerez 81 ? Daniele Campa 82 ? Gabriele Buda 76 ? Fabienne Lesueur 83 ? Marek Dudzi?ski 84 ? Ramón García-Sanz 85 ? Arnon Nagler 86 ? Marcin Rymko 87 ? Krzysztof Jamroziak 75 ? Aleksandra Butrym 88 ?, vol.17, p.9

. Service-d'hematologie, 34 Unite d'Hematologie, CH Valence, Archet Hospital

, Service d'Hematologie

H. Department and Y. Chu-ucl-namur, France 39 Departement d'oncologie, CHUV, Lausanne, Switzerland 40 Unite d'oncologie medicale, Pôle medical 2

S. Hematologie, L. Institut-de-cancerologie, and . Neuwirth,

C. Hematologie and . Abbeville,

D. Institut and . Hollard,

W. Service-hemato/oncologie and . Morey, Chalon sur Saône, France 46 Hematologie clinique, Hôpital Avicenne

, Intergroupe Francophone du Myelome (IFM)

S. Hematologie and . Bligny,

S. Hematologie, . Ch-lyon, P. Sud, and . Benite,

. Laboratoire-de-biologie-medicale-oncogènauvergne,

, Departement d'oncogenetique, UMR INSERM 1240