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News and meta-analysis regarding anti-Beta 2 glycoprotein I antibodies and their determination

Abstract : Recent advances allow us to propose antibodies targeting beta-2-glycoprotein I (β2-GPI) as the most specific antibodies associated with anti-phospholipid syndrome (APS). Therefore, there is now a crucial need for powerful biological assays to adequately monitor them. It is well established that these antibodies recognize mainly cryptic epitopes, which requires a great deal of consideration in the choice of laboratory tests to identify these antibodies. To this end, an update on the pathophysiological role of β2-GPI and a meta-analysis were conducted providing an overview of the current progress towards anti-β2-GPI detection.
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Submitted on : Monday, October 25, 2021 - 1:20:01 PM
Last modification on : Wednesday, November 3, 2021 - 6:28:32 AM
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Eléonore Bettacchioli, Salma Nafai, Renaudineau Yves. News and meta-analysis regarding anti-Beta 2 glycoprotein I antibodies and their determination. Clinical Immunology, Elsevier, 2019, ⟨10.1016/j.clim.2019.06.002⟩. ⟨hal-02156349⟩

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