STIM1 at the plasma membrane as a new target in progressive chronic lymphocytic leukemia

Abstract : Dysregulation in calcium (Ca2+) signaling is a hallmark of chronic lymphocytic leukemia (CLL). While the role of the B cell receptor (BCR) Ca2+ pathway has been associated with disease progression, the importance of the newly described constitutive Ca2+ entry (CE) pathway is less clear. In addition, we hypothesized that these differences reflect modifications of the CE pathway and Ca2+ actors such as Orai1, transient receptor potential canonical (TRPC) 1, and stromal interaction molecule 1 (STIM1), the latter being the focus of this study.
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https://hal.univ-brest.fr/hal-02114358
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Submitted on : Monday, April 29, 2019 - 3:40:45 PM
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Marjolaine Debant, Miguel Burgos, Patrice Hémon, Paul Buscaglia, Tinhinane Fali, et al.. STIM1 at the plasma membrane as a new target in progressive chronic lymphocytic leukemia. Journal for Immunotherapy of Cancer, London : BioMed Central, 2013-, 2019, 7 (1), pp.111. ⟨10.1186/s40425-019-0591-3⟩. ⟨hal-02114358⟩

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