Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

William Busse; Peter Barker; Stephanie Sproule; Richard Olsson; Ubaldo Martin; Mitchell Goldman; Anahí Yañez; Marcelo Fernández; Alberto Tolcachier; Juan Belloni; Jorge Taborda; Maria de Salvo; Jorge Maspero; Carlos Victorio; Miguel Chirino Navarta; Monica Grilli; Pablo Rodríguez; María Otaola; Víctor Cambursano; Patricia Malamud; Ana Stok; German Arce; Osiris Roza; Fernando Scherbovsky; Pedro Elias; Maria Saez; Peter Peters; John Upham; Peter Gibson; Francis Thien; Jo Douglass; Paul Thomas; Philip Bardin; Dimitar Sajkov; Mark Hew; David Langton; Andreia Pez; Carlos Fritscher; Jorge Hetzel; Waldo Mattos; Rafael Stelmach; Martti Antila; Ana Fernandes; Hristo Metev; Yavor Ivanov; Aneliya Bogdanova; Ana Markova; Marinka Peneva; Rumyana Veselinova; Tatyana Petkova; Vanushka Petrova; Elena Shopova; Yuliya Ivanov; Rumyana Yotsova; Ginka Kirkova; Galina Petrova; Svetoslav Dachev; Kostadinka Sotirova; Mariyana Stoyanova; Oleg Yakov; Vanya Ilieva-Fartunova; Catherine Lemiere; Michel Laviolette; William Yang; J Mark Fitzgerald; Bonavuth Pek; William Killorn; Claude Poirier; Guy Chouinard; Lyle Melenka; Richard Leigh; Parameswaran Nair; Delbert Dorscheid; Juan Pavie; Andres Rosenblut; Claudia Cartagena; Carlos Quilodran; Silvia Muñoz; Ivana Malkusova; Jo Veverka; Stanislav Holub; Jaroslav Mares; Radovan Kozel; Daniela Kopecka; Vladimir Zindr; Pavel Cerva; Pascal Chanez; Arnaud Bourdin; Gilles Devouassoux; Camille Taillé; Fréderic de Blay; François Goupil; Christophe Leroyer; Delphine Gourcerol; Toufik Didi; Alain Didi; Gilles Garcia; Philip Bonniaud; Riazate Rossanaly Vasram; Marek Lommatzsch; Ulf Harnest; Anneliese Linnhoff; Claus Keller; Gerhard Hoheisel; Karin Förster; Thomas Thomas; Isabelle Schenkenberger; Jo Kirschner; Tibor Schmoller; Stefan Zielen; Marc Kornmann; Ekkehard Beck; Lutz Volgmann; Rolf Dichmann; Axel Overlack; Jörg Winkler; Petra Mikloweit; Sabine Ballenberger; Mathias Rolke; Stephanie Korn; Helmut Pabel; Martin Martin; Jan Feimer; Klaus Rabe; Regina Deckelmann; Tobias Welte; Hiroyuki Ohbayashi; Soichiro Hozawa; Terufumi Shimoda; Makoto Yoshida; Toshikazu Nagakura; Tadashi Kamei; Yasuyuki Sano; Shinichiro Kagami; Hisaho Takahashi; Michiko Haida; Goro Kimura; Hiroyuki Nakamura; Yasuo To; Masaharu Shinkai; Tadasuke Shimokawaji; Makoto Kudo; Noriharu Shijyubo; Takao To; Motokazu Kato; Akihiko Tanaka; Yasuhiro Gon; Norihisa Sasaki; Tetsuro Ohdaira; Chiharu Omori; Toshiki Takahashi; Satomi Takeuchi; Kiyotaka Nakajima; Hironi Makita; Masahiro Kaneko; Kenjiro Furuta; Masami Taniguchi; Yoshito Inobe; Hiroshi Miki; Yoichi Nakamura; Naoki Miyazawa; Shuichi Yano; Masayuki Iijima; Tsuyoshi Yamato; Javier Diaz; Alberto Matsuno; Efrain Felix; Alfredo Guerreros; Alejandro Daly; Fernando Rodriguez Chariarse; Danilo Salazar; Socorro Castro; William Chavez; Rolando Estrella; Teresita Aquino; Tito Atienza; Ronnie Samoro; Marie Grace Dawn Isidro; Piotr Kuna; Adam Antczak; Michał Bednarek; Danuta Mądra-Rogacka; Teresa Hofman; Marek Jutel; Ewa Pisarczyk-Bogacka; Agata Kot; Robert Mróz; Małgorzata Czupryńska-Borkowska; Małgorzata Żurowska-Gębala; Andrzej Dyczek; Grażyna Jasieniak-Pinis; Piotr Wojnowski; Ewa Trębas-Pietraś; Małgorzata Dobryniewska; Marc Stobiecki; Marzenna Tarnowska-Matusiak; Alina Magner; Andrzej Kolczyński; Zbigniew Bartuzi; Bernadetta Majorek-Olechowska; Paweł Śliwiński; Violetta Balicka; Elżbieta Hajoł; Jacek Stachera; Marta Rachel; Marek Michnar; Jarosław Tałałaj; Ewa Springer; Piotr Napora; Renata Bijata-Bronisz; Anna Świderska; Grzegorz Mincewicz; Zbigniew Sankowski; Tomasz To; Artur Kwaśniewski; Jo Jerzyńska; Jerzy Cygler; Ryszard Olesiejuk; Iwona von Steiner; Wojciech Machowiak; Krzysztof Filipek; Piotr Piskorz; Ewa Uhryn; Marita Nittner-Marszalska; Elżbieta Rybicka-Liszewska; Anna Bodzenta-Łukaszyk; Marta Chełmińska; Izabella Krupa-Borek; Wojciech Skucha; Anna Płoszczuk; Traian Mihaescu; Ioan Dorin Petrui; Angelica Savu; Ghiulten Apti; Claudia To; Ana Trailescu; Sergei Sokurenko; Vasiliy Trofimov; Igor Leshchenko; Natalia Shaporova; Inna Ilyashevich; Irina Stitsenko; Alexander Vizel; Yulia Ilkovich; Dmitrii Tikhanov; Svetlana Gon; Andrey Ezhov; Galina Ignatova; Nadezhda Izmozherova; Nadezhda Berdnikova; Ludmila Goryachkina; Veronika Popova; Laura Bolieva; Andrey Rebrov; Vladimir Nosov; Olga Magnitskaya; Sergey Nedogoda; Vladimir Abrosimov; Artem Molotkov; Galina Reshedko; Mikhail Smirnov; Marina Osipenko; Elena Pavlysh; Svetlana Myasoedova; Liudmila Lenskaya; Valery Chistyakov; Elena Vishneva; Liliya Uon; Anna Zateyschikova; Svetlana Laleko; Tatiana Pak; Axel Bruning; Visvakuren Naidoo; Jeevren Reddy; Richard van Zyl Smit; Hae-Sim Park; Jo Cho; Sang-Heon Cho; Sang Haak Lee; Byung Jae Lee; Ju Sang Kim; You Sook Cho; Choon-Sik Park; Mi-Kyeong Kim; Young-Il Koh; Jo Kim; Sook Young Lee; Sang Pyo Lee; Jung Won Park; Kwang Ha Yoo; Hyoungkyu Yoo; Jaechun Lee; Gyu-Young Hur; Soo Keol Lee; Heekyoo Kim; David Ramos Barbón; Elena Laffond Yges; Eva Martínez Moragón; Miguel Arias Guillen; Alberto Saura Vinuesa; Fernando To; Jo Velasco Garrido; Borja García-Cosio Piqueras; Luis Pérez de Llano; Luis Valero Santiago; Myriam Calle Rubio; Leif Bjermer; Bo Lundbäck; Bilun Gemicioglu; Sevim Bavbek; Dane Ediger; Munevver Erdinc; Ismail Hanta; Sibel Nayci; Sibel Arinc; Liudmyla Iashyna; Yuriy Mostovoy; Mykola Ostrovskyy; Lesia Kuryk; Ivan Lemko; Tetyana Ospanova; Liubov Moskalenko; Oleksii Korzh; Viktor Blazhko; Olena Krakhmalova; Liliia Romaniuk; Yevgeniya Dytyatkovs'Ka; Oleh Yakov; Volodymyr Gavrysyuk; Hassan Burhan; Dinesh Saralaya; Stephen Scott; Alyn Morice; Ewa Jackson-Voyzey; Thida Win; Shuab Nasser; Richard Harrison; Rekha Chaudhuri; Monica Nordstrom; Pradip De; Matthew Masoli; Adel Mansur; Anthony Gunstone; Robert Niven; Timothy Harrison; Suresh Babu; Subodh Bhuchar; Shahrukh Kureishy; John Zwetchkenbaum; Lawrence Kaplan; Eugene Bleecker; Santiago Reyes; Faisal Fakih; Marvin Heuer; Ryan Klein; Marc Marcus; Iftikhar Hussain; Tonny To; Hengameh Raissy; Sady Alpizar; Hector Rodriguez; Gerald Gleich; Tracy Bridges; Jo Pouzar; Gary Steven; Jo Matz; Shana Krstevska; Dama Ziworitin; Adolfo Kaplan; James Sublett; James De; Amy Darter; John Agaiby; John Hagan; Enrique Davis; Dareen Siri; Charlene Mcevoy; Chrisette Dharma; Najmuddin Karimjee; Steven Steven; Manuel Frade; Amy Silverthorn; Jo Kline; Francis Averill; Jo Ruiz; Emory Robinette; Zeeshan Shaikh; Carlos Aguilar; William Nish; German Alvarez; Ismail Ismail; Purvi Parikh; Mila Leong; Dennis De; Francis Garcia; Alan Goldsobel; Antonio Blanco; Edward Campbell; Guido Perez; Geoffrey Chupp; Toby To; Vandely Perez; Sally Wenzel; Kartik Shenoy; Rohit Katial; David Bernstein; Neil Parikh; William Sims; Gary Ferguson; David Pham; Anu George; Richard Beasley; Gilberto Pérez; Robert Garver; Miriam Garcia; Stephen Wong; Weily Soong; Richard Guillot; Golda Hudes; Ahmed Arif; Jo Binker; Manuel Villareal; Ulrike Ziegner; Jo Ojile; Sanjeev Goswami; Carlos Piniella; Ilia Segal; Heidi Zafra; Mitchell Lee; Martha Tarpay; John Panuto; Rajan Merchant; Peter Springsteen; Timothy Scialla; Paul Shapero; Karen Allen; Mark Moss; Humberto Cruz; Jeffrey Rumbyrt; Bo Boyd; Robert Nathan; Jo Bernstein; Jo Jacobs; Elliot Ginchansky; John Johnston; Barbara Baxter; John Thomas; Stephen Apaliski; Clinton Corder; David Fuentes; Jo Diaz; Chau Ngo; Lan Le

Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

William Busse ¹ Peter Barker Stephanie Sproule Richard Olsson Ubaldo Martin Mitchell Goldman Anahí Yañez Marcelo Fernández Alberto Tolcachier Juan Belloni Jorge Taborda Maria de Salvo Jorge Maspero ² Carlos Victorio Miguel Chirino Navarta Monica Grilli Pablo Rodríguez María Otaola Víctor Cambursano Patricia Malamud Ana Stok German Arce Osiris Roza Fernando Scherbovsky Pedro Elias Maria Saez Peter Peters ³ John Upham Peter Gibson ⁴ Francis Thien Jo Douglass Paul Thomas ⁵ Philip Bardin Dimitar Sajkov Mark Hew David Langton Andreia Pez Carlos Fritscher Jorge Hetzel Waldo Mattos Rafael Stelmach Martti Antila Ana Fernandes ⁶ Hristo Metev Yavor Ivanov Aneliya Bogdanova Ana Markova Marinka Peneva Rumyana Veselinova Tatyana Petkova Vanushka Petrova Elena Shopova Yuliya Ivanov Rumyana Yotsova Ginka Kirkova Galina Petrova Svetoslav Dachev Kostadinka Sotirova Mariyana Stoyanova Oleg Yakov Vanya Ilieva-Fartunova Catherine Lemiere Michel Laviolette William Yang J Mark Fitzgerald Bonavuth Pek William Killorn Claude Poirier ⁷ Guy Chouinard Lyle Melenka Richard Leigh ⁸ Parameswaran Nair Delbert Dorscheid Juan Pavie Andres Rosenblut Claudia Cartagena Carlos Quilodran Silvia Muñoz Ivana Malkusova Jo Veverka Stanislav Holub Jaroslav Mares Radovan Kozel Daniela Kopecka Vladimir Zindr Pavel Cerva Pascal Chanez ⁹ Arnaud Bourdin ¹⁰ Gilles Devouassoux ¹¹ Camille Taillé ¹² Fréderic de Blay ¹³ François Goupil ¹⁴ Christophe Leroyer ^{15, 16} Delphine Gourcerol Toufik Didi ¹⁷ Alain Didi Gilles Garcia ¹⁸ Philip Bonniaud Riazate Rossanaly Vasram Marek Lommatzsch Ulf Harnest Anneliese Linnhoff Claus Keller Gerhard Hoheisel Karin Förster Thomas Thomas Isabelle Schenkenberger Jo Kirschner Tibor Schmoller Stefan Zielen ¹⁹ Marc Kornmann Ekkehard Beck Lutz Volgmann Rolf Dichmann Axel Overlack Jörg Winkler Petra Mikloweit Sabine Ballenberger Mathias Rolke Stephanie Korn Helmut Pabel Martin Martin Jan Feimer Klaus Rabe ²⁰ Regina Deckelmann Tobias Welte ²¹ Hiroyuki Ohbayashi Soichiro Hozawa Terufumi Shimoda Makoto Yoshida Toshikazu Nagakura Tadashi Kamei Yasuyuki Sano Shinichiro Kagami Hisaho Takahashi Michiko Haida Goro Kimura Hiroyuki Nakamura ²² Yasuo To Masaharu Shinkai Tadasuke Shimokawaji Makoto Kudo Noriharu Shijyubo Takao To Motokazu Kato Akihiko Tanaka Yasuhiro Gon Norihisa Sasaki Tetsuro Ohdaira Chiharu Omori Toshiki Takahashi Satomi Takeuchi Kiyotaka Nakajima Hironi Makita Masahiro Kaneko Kenjiro Furuta Masami Taniguchi Yoshito Inobe Hiroshi Miki Yoichi Nakamura Naoki Miyazawa Shuichi Yano Masayuki Iijima Tsuyoshi Yamato Javier Diaz Alberto Matsuno Efrain Felix Alfredo Guerreros Alejandro Daly Fernando Rodriguez Chariarse Danilo Salazar Socorro Castro William Chavez Rolando Estrella Teresita Aquino Tito Atienza Ronnie Samoro Marie Grace Dawn Isidro Piotr Kuna ²³ Adam Antczak Michał Bednarek Danuta Mądra-Rogacka Teresa Hofman Marek Jutel ²⁴ Ewa Pisarczyk-Bogacka Agata Kot Robert Mróz Małgorzata Czupryńska-Borkowska Małgorzata Żurowska-Gębala Andrzej Dyczek Grażyna Jasieniak-Pinis Piotr Wojnowski Ewa Trębas-Pietraś Małgorzata Dobryniewska Marc Stobiecki Marzenna Tarnowska-Matusiak Alina Magner Andrzej Kolczyński Zbigniew Bartuzi Bernadetta Majorek-Olechowska Paweł Śliwiński Violetta Balicka Elżbieta Hajoł Jacek Stachera Marta Rachel Marek Michnar Jarosław Tałałaj Ewa Springer Piotr Napora Renata Bijata-Bronisz Anna Świderska Grzegorz Mincewicz Zbigniew Sankowski Tomasz To Artur Kwaśniewski Jo Jerzyńska Jerzy Cygler Ryszard Olesiejuk Iwona von Steiner Wojciech Machowiak Krzysztof Filipek Piotr Piskorz Ewa Uhryn Marita Nittner-Marszalska Elżbieta Rybicka-Liszewska Anna Bodzenta-Łukaszyk Marta Chełmińska Izabella Krupa-Borek Wojciech Skucha Anna Płoszczuk Traian Mihaescu Ioan Dorin Petrui Angelica Savu Ghiulten Apti Claudia To Ana Trailescu Sergei Sokurenko Vasiliy Trofimov Igor Leshchenko Natalia Shaporova Inna Ilyashevich Irina Stitsenko Alexander Vizel Yulia Ilkovich Dmitrii Tikhanov Svetlana Gon Andrey Ezhov Galina Ignatova Nadezhda Izmozherova Nadezhda Berdnikova Ludmila Goryachkina Veronika Popova Laura Bolieva Andrey Rebrov Vladimir Nosov Olga Magnitskaya Sergey Nedogoda Vladimir Abrosimov Artem Molotkov Galina Reshedko Mikhail Smirnov ²⁵ Marina Osipenko Elena Pavlysh Svetlana Myasoedova Liudmila Lenskaya Valery Chistyakov Elena Vishneva Liliya Uon Anna Zateyschikova Svetlana Laleko Tatiana Pak Axel Bruning Visvakuren Naidoo Jeevren Reddy Richard van Zyl Smit Hae-Sim Park Jo Cho Sang-Heon Cho Sang Haak Lee Byung Jae Lee Ju Sang Kim You Sook Cho Choon-Sik Park Mi-Kyeong Kim Young-Il Koh Jo Kim Sook Young Lee Sang Pyo Lee Jung Won Park Kwang Ha Yoo Hyoungkyu Yoo Jaechun Lee Gyu-Young Hur Soo Keol Lee Heekyoo Kim David Ramos Barbón Elena Laffond Yges Eva Martínez Moragón Miguel Arias Guillen Alberto Saura Vinuesa Fernando To Jo Velasco Garrido Borja García-Cosio Piqueras Luis Pérez de Llano Luis Valero Santiago Myriam Calle Rubio Leif Bjermer Bo Lundbäck Bilun Gemicioglu Sevim Bavbek ²⁶ Dane Ediger Munevver Erdinc Ismail Hanta Sibel Nayci Sibel Arinc Liudmyla Iashyna Yuriy Mostovoy Mykola Ostrovskyy Lesia Kuryk Ivan Lemko Tetyana Ospanova Liubov Moskalenko Oleksii Korzh Viktor Blazhko Olena Krakhmalova Liliia Romaniuk Yevgeniya Dytyatkovs'Ka Oleh Yakov Volodymyr Gavrysyuk Hassan Burhan Dinesh Saralaya Stephen Scott ²⁷ Alyn Morice Ewa Jackson-Voyzey Thida Win Shuab Nasser Richard Harrison ²⁸ Rekha Chaudhuri Monica Nordstrom Pradip De Matthew Masoli Adel Mansur Anthony Gunstone Robert Niven Timothy Harrison Suresh Babu Subodh Bhuchar Shahrukh Kureishy John Zwetchkenbaum Lawrence Kaplan Eugene Bleecker ²⁹ Santiago Reyes ³⁰ Faisal Fakih Marvin Heuer Ryan Klein Marc Marcus Iftikhar Hussain ³¹ Tonny To Hengameh Raissy Sady Alpizar Hector Rodriguez ³² Gerald Gleich Tracy Bridges Jo Pouzar Gary Steven Jo Matz Shana Krstevska Dama Ziworitin Adolfo Kaplan James Sublett James De Amy Darter John Agaiby John Hagan Enrique Davis Dareen Siri Charlene Mcevoy Chrisette Dharma Najmuddin Karimjee Steven Steven Manuel Frade Amy Silverthorn Jo Kline Francis Averill Jo Ruiz Emory Robinette Zeeshan Shaikh Carlos Aguilar William Nish German Alvarez Ismail Ismail Purvi Parikh Mila Leong Dennis De Francis Garcia ³³ Alan Goldsobel Antonio Blanco Edward Campbell Guido Perez Geoffrey Chupp Toby To Vandely Perez Sally Wenzel Kartik Shenoy Rohit Katial David Bernstein Neil Parikh William Sims Gary Ferguson David Pham Anu George Richard Beasley Gilberto Pérez ³⁴ Robert Garver Miriam Garcia Stephen Wong Weily Soong Richard Guillot Golda Hudes Ahmed Arif Jo Binker Manuel Villareal Ulrike Ziegner Jo Ojile Sanjeev Goswami Carlos Piniella Ilia Segal Heidi Zafra Mitchell Lee Martha Tarpay John Panuto Rajan Merchant Peter Springsteen Timothy Scialla Paul Shapero Karen Allen Mark Moss Humberto Cruz Jeffrey Rumbyrt Bo Boyd Robert Nathan Jo Bernstein Jo Jacobs Elliot Ginchansky John Johnston Barbara Baxter John Thomas Stephen Apaliski Clinton Corder David Fuentes Jo Diaz Chau Ngo Lan Le

1 Department of Medicine

2 Fundación Cidea Allergy and Respiratory Research Unit,

3 University of Oxford [Oxford]

4 University of Newcastle, Newcastle, NSW Australia.

5 Dstl - Defence Science and Technology Laboratory

6 Organização Multinacional de Formação

7 AUF - Agence Universitaire de la Francophonie

8 University of Calgary,

9 C2VN - Centre recherche en CardioVasculaire et Nutrition

10 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]

11 laboratoire du sommeil

12 Physiopathologie et Epidémiologie des Maladies Respiratoires

13 CHU Strasbourg

14 Centre Hospitalier du Mans

15 GETBO - Groupe d'Etude de la Thrombose de Bretagne Occidentale

16 CIC Brest

17 Service de pneumologie

18 Cytokines, chimiokines et immunopathologie

19 J.W. Goethe Universität, Institut für Geowissenschaften, Altenhöferallee 1, D-60438 Frankfurt am Main, Germany

20 Department of Pulmonary Medicine

21 Department of Pulmonary Medicine

22 Japan Energy Corporation

23 MUL - Medical University of Łódź

24 Wroclaw Medical University

25 Saint-Petersburg State University, Physical Department, Petrodvoretz, 194508 St.-Petersburg, Russia

PD - Physical Department

26 Ankara University

27 ORNL - Oak Ridge National Laboratory [Oak Ridge]

28 Department of Earth Sciences, University of Cambridge

29 Center for Genomics and Personalized Medicine

30 Mayo Clinic [Rochester]

31 Department of Wildlife Management

32 Lab Biotecnol Bacteriana, Inst Ciencia & Tecnol Alimentos & Nutr ICTAN

33 CEMMC - Centre d'études des mondes moderne et contemporain

34 Universidade da Coruña

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

Life Sciences [q-bio] / Human health and pathology

Life Sciences [q-bio] / Human health and pathology / Pulmonology and respiratory tract

Complete list of metadatas

https://hal.univ-brest.fr/hal-02052347
Contributor : Ghislaine Calvez <>
Submitted on : Thursday, February 28, 2019 - 2:08:24 PM
Last modification on : Thursday, July 11, 2019 - 9:15:01 AM

Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

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Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

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