Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial - Université de Bretagne Occidentale Access content directly
Journal Articles The Lancet Respiratory Medicine Year : 2019

Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

William Busse (1) , Peter Barker , Stephanie Sproule , Richard Olsson , Ubaldo Martin , Mitchell Goldman , Anahí Yañez , Marcelo Fernández , Alberto Tolcachier , Juan Belloni , Jorge Taborda , Maria de Salvo , Jorge Maspero (2) , Carlos Victorio , Miguel Chirino Navarta , Monica Grilli , Pablo Rodríguez , María Otaola , Víctor Cambursano , Patricia Malamud , Ana Stok , German Arce , Osiris Roza , Fernando Scherbovsky , Pedro Elias , Maria Saez , Peter Peters (3) , John Upham , Peter Gibson (4) , Francis Thien , Jo Douglass , Paul Thomas (5) , Philip Bardin , Dimitar Sajkov , Mark Hew , David Langton , Andreia Pez , Carlos Fritscher , Jorge Hetzel , Waldo Mattos , Rafael Stelmach , Martti Antila , Ana Fernandes (6) , Hristo Metev , Yavor Ivanov , Aneliya Bogdanova , Ana Markova , Marinka Peneva , Rumyana Veselinova , Tatyana Petkova , Vanushka Petrova , Elena Shopova , Yuliya Ivanov , Rumyana Yotsova , Ginka Kirkova , Galina Petrova , Svetoslav Dachev , Kostadinka Sotirova , Mariyana Stoyanova , Oleg Yakov , Vanya Ilieva-Fartunova , Catherine Lemiere , Michel Laviolette , William Yang , J Mark Fitzgerald , Bonavuth Pek , William Killorn , Claude Poirier (7) , Guy Chouinard , Lyle Melenka , Richard Leigh (8) , Parameswaran Nair , Delbert Dorscheid , Juan Pavie , Andres Rosenblut , Claudia Cartagena , Carlos Quilodran , Silvia Muñoz , Ivana Malkusova , Jo Veverka , Stanislav Holub , Jaroslav Mares , Radovan Kozel , Daniela Kopecka , Vladimir Zindr , Pavel Cerva , Pascal Chanez (9) , Arnaud Bourdin (10, 11) , Gilles Devouassoux (12) , Camille Taillé (13) , Fréderic de Blay (14) , François Goupil (15) , Christophe Leroyer (16, 17) , Delphine Gourcerol , Toufik Didi (18) , Alain Didi , Gilles Garcia (19) , Philip Bonniaud , Riazate Rossanaly Vasram , Marek Lommatzsch , Ulf Harnest , Anneliese Linnhoff , Claus Keller , Gerhard Hoheisel , Karin Förster , Thomas Thomas , Isabelle Schenkenberger , Jo Kirschner , Tibor Schmoller , Stefan Zielen (20) , Marc Kornmann , Ekkehard Beck , Lutz Volgmann , Rolf Dichmann , Axel Overlack , Jörg Winkler , Petra Mikloweit , Sabine Ballenberger , Mathias Rolke , Stephanie Korn , Helmut Pabel , Martin Martin , Jan Feimer , Klaus F. Rabe (21) , Regina Deckelmann , Tobias Welte (22) , Hiroyuki Ohbayashi , Soichiro Hozawa , Terufumi Shimoda , Makoto Yoshida , Toshikazu Nagakura , Tadashi Kamei , Yasuyuki Sano , Shinichiro Kagami , Hisaho Takahashi , Michiko Haida , Goro Kimura , Hiroyuki Nakamura (23) , Yasuo To , Masaharu Shinkai , Tadasuke Shimokawaji , Makoto Kudo , Noriharu Shijyubo , Takao To , Motokazu Kato , Akihiko Tanaka , Yasuhiro Gon , Norihisa Sasaki , Tetsuro Ohdaira , Chiharu Omori , Toshiki Takahashi , Satomi Takeuchi , Kiyotaka Nakajima , Hironi Makita , Masahiro Kaneko , Kenjiro Furuta , Masami Taniguchi , Yoshito Inobe , Hiroshi Miki , Yoichi Nakamura , Naoki Miyazawa , Shuichi Yano , Masayuki Iijima , Tsuyoshi Yamato , Javier Diaz , Alberto Matsuno , Efrain Felix , Alfredo Guerreros , Alejandro Daly , Fernando Rodriguez Chariarse , Danilo Salazar , Socorro Castro , William Chavez , Rolando Estrella , Teresita Aquino , Tito Atienza , Ronnie Samoro , Marie Grace Dawn Isidro , Piotr Kuna (24) , Adam Antczak , Michał Bednarek , Danuta Mądra-Rogacka , Teresa Hofman , Marek Jutel (25) , Ewa Pisarczyk-Bogacka , Agata Kot , Robert Mróz , Małgorzata Czupryńska-Borkowska , Małgorzata Żurowska-Gębala , Andrzej Dyczek , Grażyna Jasieniak-Pinis , Piotr Wojnowski , Ewa Trębas-Pietraś , Małgorzata Dobryniewska , Marc Stobiecki , Marzenna Tarnowska-Matusiak , Alina Magner , Andrzej Kolczyński , Zbigniew Bartuzi , Bernadetta Majorek-Olechowska , Paweł Śliwiński , Violetta Balicka , Elżbieta Hajoł , Jacek Stachera , Marta Rachel , Marek Michnar , Jarosław Tałałaj , Ewa Springer , Piotr Napora , Renata Bijata-Bronisz , Anna Świderska , Grzegorz Mincewicz , Zbigniew Sankowski , Tomasz To , Artur Kwaśniewski , Jo Jerzyńska , Jerzy Cygler , Ryszard Olesiejuk , Iwona von Steiner , Wojciech Machowiak , Krzysztof Filipek , Piotr Piskorz , Ewa Uhryn , Marita Nittner-Marszalska , Elżbieta Rybicka-Liszewska , Anna Bodzenta-Łukaszyk , Marta Chełmińska , Izabella Krupa-Borek , Wojciech Skucha , Anna Płoszczuk , Traian Mihaescu , Ioan Dorin Petrui , Angelica Savu , Ghiulten Apti , Claudia To , Ana Trailescu , Sergei Sokurenko , Vasiliy Trofimov , Igor Leshchenko , Natalia Shaporova , Inna Ilyashevich , Irina Stitsenko , Alexander Vizel , Yulia Ilkovich , Dmitrii Tikhanov , Svetlana Gon , Andrey Ezhov , Galina Ignatova , Nadezhda Izmozherova , Nadezhda Berdnikova , Ludmila Goryachkina , Veronika Popova , Laura Bolieva , Andrey Rebrov , Vladimir Nosov , Olga Magnitskaya , Sergey Nedogoda , Vladimir Abrosimov , Artem Molotkov , Galina Reshedko , Mikhail Smirnov (26) , Marina Osipenko , Elena Pavlysh , Svetlana Myasoedova , Liudmila Lenskaya , Valery Chistyakov , Elena Vishneva , Liliya Uon , Anna Zateyschikova , Svetlana Laleko , Tatiana Pak , Axel Bruning , Visvakuren Naidoo , Jeevren Reddy , Richard van Zyl Smit , Hae-Sim Park , Jo Cho , Sang-Heon Cho , Sang Haak Lee , Byung Jae Lee , Ju Sang Kim , You Sook Cho , Choon-Sik Park , Mi-Kyeong Kim , Young-Il Koh , Jo Kim , Sook Young Lee , Sang Pyo Lee , Jung Won Park , Kwang Ha Yoo , Hyoungkyu Yoo , Jaechun Lee , Gyu-Young Hur , Soo Keol Lee , Heekyoo Kim , David Ramos Barbón , Elena Laffond Yges , Eva Martínez Moragón , Miguel Arias Guillen , Alberto Saura Vinuesa , Fernando To , Jo Velasco Garrido , Borja García-Cosio Piqueras , Luis Pérez de Llano , Luis Valero Santiago , Myriam Calle Rubio , Leif Bjermer , Bo Lundbäck , Bilun Gemicioglu , Sevim Bavbek (27) , Dane Ediger , Munevver Erdinc , Ismail Hanta , Sibel Nayci , Sibel Arinc , Liudmyla Iashyna , Yuriy Mostovoy , Mykola Ostrovskyy , Lesia Kuryk , Ivan Lemko , Tetyana Ospanova , Liubov Moskalenko , Oleksii Korzh , Viktor Blazhko , Olena Krakhmalova , Liliia Romaniuk , Yevgeniya Dytyatkovs'Ka , Oleh Yakov , Volodymyr Gavrysyuk , Hassan Burhan , Dinesh Saralaya , Stephen L. Scott (28) , Alyn Morice , Ewa Jackson-Voyzey , Thida Win , Shuab Nasser , Richard Harrison (29) , Rekha Chaudhuri , Monica Nordstrom , Pradip De , Matthew Masoli , Adel Mansur , Anthony Gunstone , Robert Niven , Timothy Harrison , Suresh Babu , Subodh Bhuchar , Shahrukh Kureishy , John Zwetchkenbaum , Lawrence Kaplan , Eugene R. Bleecker (30) , Santiago Reyes (31) , Faisal Fakih , Marvin Heuer , Ryan Klein , Marc Marcus , Iftikhar Hussain (32) , Tonny To , Hengameh Raissy , Sady Alpizar , Hector H. Rodriguez (33) , Gerald Gleich , Tracy Bridges , Jo Pouzar , Gary Steven , Jo Matz , Shana Krstevska , Dama Ziworitin , Adolfo Kaplan , James Sublett , James De , Amy Darter , John Agaiby , John Hagan , Enrique Davis , Dareen Siri , Charlene Mcevoy , Chrisette Dharma , Najmuddin Karimjee , Steven Steven , Manuel Frade , Amy Silverthorn , Jo Kline , Francis Averill , Jo Ruiz , Emory Robinette , Zeeshan Shaikh , Carlos Aguilar , William Nish , German Alvarez , Ismail Ismail , Purvi Parikh , Mila Leong , Dennis De , Francis Garcia , Alan Goldsobel , Antonio Blanco , Edward Campbell , Guido Perez , Geoffrey Chupp , Toby To , Vandely Perez , Sally Wenzel , Kartik Shenoy , Rohit Katial , David Bernstein , Neil Parikh , William Sims , Gary Ferguson , David Pham , Anu George , Richard Beasley , Gilberto Pérez (34) , Robert Garver , Miriam Garcia , Stephen Wong , Weily Soong , Richard Guillot , Golda Hudes , Ahmed Arif , Jo Binker , Manuel Villareal , Ulrike Ziegner , Jo Ojile , Sanjeev Goswami , Carlos Piniella , Ilia Segal , Heidi Zafra , Mitchell Lee , Martha Tarpay , John Panuto , Rajan Merchant , Peter Springsteen , Timothy Scialla , Paul Shapero , Karen Allen , Mark Moss , Humberto Cruz , Jeffrey Rumbyrt , Bo Boyd , Robert Nathan , Jo Bernstein , Jo Jacobs , Elliot Ginchansky , John Johnston , Barbara Baxter , John Thomas , Stephen Apaliski , Clinton Corder , David Fuentes , Jo Diaz , Chau Ngo , Lan Le
1 Department of Medicine
2 Fundación Cidea Allergy and Respiratory Research Unit,
3 University of Oxford
4 UoN - University of Newcastle [Callaghan, Australia]
5 Dstl - Defence Science and Technology Laboratory
6 Organização Multinacional de Formação
7 AUF - Agence Universitaire de la Francophonie
8 University of Calgary
9 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
10 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
11 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
12 laboratoire du sommeil
13 PHERE (UMR_S_1152 / U1152) - Physiopathologie et Epidémiologie des Maladies Respiratoires
14 CHU Strasbourg
15 Centre Hospitalier du Mans
16 GETBO - Groupe d'Etude de la Thrombose de Bretagne Occidentale
17 CIC Brest
18 Service de pneumologie
19 Cytokines, chimiokines et immunopathologie
20 J.W. Goethe Universität, Institut für Geowissenschaften, Altenhöferallee 1, D-60438 Frankfurt am Main, Germany
21 Department of Pulmonary Medicine
22 Department of Pulmonary Medicine
23 Japan Energy Corporation
24 MUL - Medical University of Łódź
25 Wrocław Medical University
26 Saint-Petersburg State University, Physical Department, Petrodvoretz, 194508 St.-Petersburg, Russia
27 Ankara University
28 ORNL - Oak Ridge National Laboratory [Oak Ridge]
29 Department of Earth Sciences [University of Cambridge]
30 Center for Genomics and Personalized Medicine
31 Mayo Clinic [Rochester]
32 Department of Wildlife Management
33 Lab Biotecnol Bacteriana, Inst Ciencia & Tecnol Alimentos & Nutr ICTAN
34 Universidade da Coruña
William Busse
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Peter Barker
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Dane Ediger
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Dates and versions

hal-02052347 , version 1 (28-02-2019)

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William Busse, Peter Barker, Stephanie Sproule, Richard Olsson, Ubaldo Martin, et al.. Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial. The Lancet Respiratory Medicine, 2019, 7 (1), pp.46-59. ⟨10.1016/S2213-2600(18)30406-5⟩. ⟨hal-02052347⟩
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