Natural course and prognosis of anaplastic gangliogliomas: a multicenter retrospective study of 43 cases from the French Brain Tumor Database - Université de Bretagne Occidentale Access content directly
Journal Articles Neuro-Oncology Year : 2017

Natural course and prognosis of anaplastic gangliogliomas: a multicenter retrospective study of 43 cases from the French Brain Tumor Database

1 INM - Institut des Neurosciences de Montpellier
2 SLA CHRU Montpellier - Centre référent Sclérose Latérale Amyotrophique [CHRU Montpellier]
3 UPD5 Médecine - Université Paris Descartes - Faculté de Médecine
4 ICM - UNICANCER - Institut régional du Cancer Montpellier Val d'Aurelle
5 PRC - Physiologie de la reproduction et des comportements [Nouzilly]
6 CIC - Centre d’Investigation Clinique [Tours] CIC 1415
7 IBV - Institut de Biologie Valrose
8 Service de Pathologie [CHU de Dijon]
9 Service de neurochirurgie [Brest]
10 CIC Brest
11 Service de Neurochirurgie [CHU Rouen]
12 Service d'anatomie pathologique et histologie-cytologie [Rangueil]
13 Sérine protéases et physiopathologie de l'unité neurovasculaire
14 Service de neurochirurgie [CHU Dijon]
15 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
16 Laboratoire de Neuropathologie
17 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
18 Service de Neurochirurgie [CHU Clermont-Ferrand]
19 COSS - Chemistry, Oncogenesis, Stress and Signaling
20 Service de neurochirurgie
21 Service Neurochirurgie [CHU Toulouse]
22 LKB (Lhomond) - Laboratoire Kastler Brossel
23 Service de neurochirurgie [CHU Angers]
24 Service de neurochirurgie [CHU Marseille]
25 CIMoTHeMA - Cibles moléculaires et thérapeutiques de la maladie d'Alzheimer
26 CRCINA-ÉQUIPE 17 - Design and Application of Innovative Local Treatments in Glioblastoma
27 MAC - Laboratoire Mouvement Adaptation Cognition
28 Cellules souches leucémiques et thérapeuthiques
29 UPD5 - Université Paris Descartes - Paris 5
30 USPC - Université Sorbonne Paris Cité
31 iBraiN - Imaging, Brain & Neuropsychiatry
32 ACPNP - Service d'Anatomo-Cyto-Pathologie et de NeuroPathologie [Hôpital de la Timone - APHM]
Louis-Marie Terrier
  • Function : Author
Luc Bauchet
Anne-Marie Bergemer-Fouquet
  • Function : Author
Eric Bord
  • Function : Author
Philippe Cornu
  • Function : Author
  • PersonId : 856089
Alain Czorny
  • Function : Author
Catherine Godfraind
  • Function : Author
  • PersonId : 927173
Kevin Janot
  • Function : Author
  • PersonId : 1033962
Dominique Liguoro
  • Function : Author
Guillaume Lot
  • Function : Author
Vincent Lubrano
  • Function : Author
  • PersonId : 935779
  • IdRef : 108136728
Emmanuel Mandonnet
Philippe Menei
  • Function : Author
  • PersonId : 910996
  • IdRef : 076585468
Philippe Metellus
  • Function : Author
  • PersonId : 1002610
Bertrand Muckenstrum
  • Function : Author
Hugues Roche
  • Function : Author
Emmanuel Uro-Coste
  • Function : Author
Jimmy Voirin
  • Function : Author
Patrick François
  • Function : Author

Abstract

Background - Anaplastic gangliogliomas (GGGs) are rare tumors whose natural history is poorly documented. We aimed to define their clinical and imaging features and to identify prognostic factors. Methods - Consecutive cases of anaplastic GGGs in adults prospectively entered into the French Brain Tumor Database between March 2004 and April 2014 were screened. After diagnosis was confirmed by pathological review, clinical, imaging, therapeutic, and outcome data were collected retrospectively. Results - Forty-three patients with anaplastic GGG (median age, 49.4 y) from 18 centers were included. Presenting symptoms were neurological deficit (37.2%), epileptic seizure (37.2%), or increased intracranial pressure (25.6%). Typical imaging findings were unifocal location (94.7%), contrast enhancement (88.1%), central necrosis (43.2%), and mass effect (47.6%). Therapeutic strategy included surgical resection (95.3%), adjuvant radiochemotherapy (48.8%), or radiotherapy alone (27.9%). Median progression-free survival (PFS) and overall survival (OS) were 8.0 and 24.7 months, respectively. Three- and 5-year tumor recurrence rates were 69% and 100%, respectively. The 5-year survival rate was 24.9%. Considering unadjusted significant prognostic factors, tumor midline crossing and frontal location were associated with shorter OS. Temporal and parietal locations were associated with longer and shorter PFS, respectively. None of these factors remained statistically significant in multivariate analysis. Conclusions - We report a large series providing clinical, imaging, therapeutic, and prognostic features of adult patients treated for an intracerebral anaplastic GGG. Our results show that pathological diagnosis is difficult, that survivals are only slightly better than for glioblastomas, and that complete surgical resection followed with adjuvant chemoradiotherapy offers longer survival.

Dates and versions

hal-02051153 , version 1 (27-02-2019)

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Louis-Marie Terrier, Luc Bauchet, Valérie Rigau, Aymeric Amelot, Sonia Zouaoui, et al.. Natural course and prognosis of anaplastic gangliogliomas: a multicenter retrospective study of 43 cases from the French Brain Tumor Database. Neuro-Oncology, 2017, 19 (5), pp.678-688. ⟨10.1093/neuonc/now186⟩. ⟨hal-02051153⟩
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