Natural course and prognosis of anaplastic gangliogliomas: a multicenter retrospective study of 43 cases from the French Brain Tumor Database
Louis-Marie Terrier
(1, 2, 3)
,
Luc Bauchet
(4)
,
Valérie Rigau
(5)
,
Aymeric Amelot
(6)
,
Sonia Zouaoui
(7)
,
Isabelle Filipiak
(8)
,
Agnès Caille
(9)
,
Fabien Almairac
(10)
,
Marie-Hélène Aubriot-Lorton
(11)
,
Anne-Marie Bergemer-Fouquet
(1)
,
Eric Bord
(12)
,
Philippe Cornu
(13)
,
Alain Czorny
(14)
,
Phong Dam Hieu
(15, 16)
,
Bertrand Debono
(17)
,
Marie-Bernadette Delisle
(18)
,
Evelyne Emery
(19)
,
Walid Farah
(20)
,
Guillaume Gauchotte
(21)
,
Catherine Godfraind
(22, 23)
,
Jacques Guyotat
(24)
,
Bernard Irthum
(25)
,
Kevin Janot
(1)
,
Pierre-Jean Le Reste
(26)
,
Dominique Liguoro
(27)
,
Hugues Loiseau
(28, 29)
,
Guillaume Lot
(30)
,
Vincent Lubrano
(31)
,
Emmanuel Mandonnet
(32)
,
Philippe Menei
(33)
,
Philippe Metellus
(34)
,
Serge Milin
(35)
,
Bertrand Muckenstrum
(36)
,
Hugues Roche
(37)
,
Audrey Rousseau
(38)
,
Emmanuel Uro-Coste
(39)
,
Anne Vital
(40)
,
Jimmy Voirin
(41)
,
Michel Wager
(42)
,
Marc Zanello
(43, 44)
,
Patrick François
(1)
,
Stéphane Velut
(3)
,
Pascale Varlet
(43, 44)
,
Dominique Figarella-Branger
(45)
,
Johan Pallud
(43, 44)
,
Ilyess Zemmoura
(3)
1
CHRU Tours -
Centre Hospitalier Régional Universitaire de Tours
2 UT - Université de Tours
3 iBraiN - Imaging, Brain & Neuropsychiatry
4 INM - Institut des Neurosciences de Montpellier
5 SLA CHRU Montpellier - Centre référent Sclérose Latérale Amyotrophique [CHRU Montpellier]
6 UPD5 Médecine - Université Paris Descartes - Faculté de Médecine
7 ICM - UNICANCER - Institut régional du Cancer Montpellier Val d'Aurelle
8 PRC - Physiologie de la reproduction et des comportements [Nouzilly]
9 CIC - Centre d’Investigation Clinique [Tours] CIC 1415
10 IBV - Institut de Biologie Valrose
11 Service de Pathologie [CHU de Dijon]
12 Service de neurochirurgie [CHU Nantes]
13 CHU Pitié-Salpêtrière [AP-HP]
14 Hôpital JeanMinjoz
15 Service de neurochirurgie [Brest]
16 CIC Brest
17 Service de Neurochirurgie [CHU Rouen]
18 Service d'anatomie pathologique et histologie-cytologie [Rangueil]
19 Sérine protéases et physiopathologie de l'unité neurovasculaire
20 Service de neurochirurgie [CHU Dijon]
21 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
22 Laboratoire de Neuropathologie
23 CHU Clermont-Ferrand
24 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
25 Service Neurochirurgie A et B [CHU Clermont-Ferrand]
26 COSS - Chemistry, Oncogenesis, Stress and Signaling
27 CHU Bordeaux - Centre Hospitalier Universitaire de Bordeaux
28 Service de neurochirurgie
29 Hôpital Pellegrin
30 Fondation Ophtalmologique Adolphe de Rothschild [Paris]
31 Service Neurochirurgie [CHU Toulouse]
32 LKB (Lhomond) - Laboratoire Kastler Brossel
33 Service de neurochirurgie [CHU Angers]
34 Service de neurochirurgie [CHU Marseille]
35 CIMoTHeMA [Poitiers] - Cibles moléculaires et thérapeutiques de la maladie d'Alzheimer [EA 3808]
36 HLSO - Hôpital La Source [Orléans]
37 Hôpital Nord [CHU - APHM]
38 CRCINA-ÉQUIPE 17 - Design and Application of Innovative Local Treatments in Glioblastoma
39 Service Anatomie et cytologie pathologiques [CHU Toulouse]
40 MAC - Laboratoire Mouvement Adaptation Cognition
41 Service de Neurologie [Hôpitaux Civils de Colmar]
42 Cellules souches leucémiques et thérapeuthiques
43 UPD5 - Université Paris Descartes - Paris 5
44 USPC - Université Sorbonne Paris Cité
45 ACPNP - Service d'Anatomo-Cyto-Pathologie et de NeuroPathologie [Hôpital de la Timone - APHM]
2 UT - Université de Tours
3 iBraiN - Imaging, Brain & Neuropsychiatry
4 INM - Institut des Neurosciences de Montpellier
5 SLA CHRU Montpellier - Centre référent Sclérose Latérale Amyotrophique [CHRU Montpellier]
6 UPD5 Médecine - Université Paris Descartes - Faculté de Médecine
7 ICM - UNICANCER - Institut régional du Cancer Montpellier Val d'Aurelle
8 PRC - Physiologie de la reproduction et des comportements [Nouzilly]
9 CIC - Centre d’Investigation Clinique [Tours] CIC 1415
10 IBV - Institut de Biologie Valrose
11 Service de Pathologie [CHU de Dijon]
12 Service de neurochirurgie [CHU Nantes]
13 CHU Pitié-Salpêtrière [AP-HP]
14 Hôpital JeanMinjoz
15 Service de neurochirurgie [Brest]
16 CIC Brest
17 Service de Neurochirurgie [CHU Rouen]
18 Service d'anatomie pathologique et histologie-cytologie [Rangueil]
19 Sérine protéases et physiopathologie de l'unité neurovasculaire
20 Service de neurochirurgie [CHU Dijon]
21 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
22 Laboratoire de Neuropathologie
23 CHU Clermont-Ferrand
24 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
25 Service Neurochirurgie A et B [CHU Clermont-Ferrand]
26 COSS - Chemistry, Oncogenesis, Stress and Signaling
27 CHU Bordeaux - Centre Hospitalier Universitaire de Bordeaux
28 Service de neurochirurgie
29 Hôpital Pellegrin
30 Fondation Ophtalmologique Adolphe de Rothschild [Paris]
31 Service Neurochirurgie [CHU Toulouse]
32 LKB (Lhomond) - Laboratoire Kastler Brossel
33 Service de neurochirurgie [CHU Angers]
34 Service de neurochirurgie [CHU Marseille]
35 CIMoTHeMA [Poitiers] - Cibles moléculaires et thérapeutiques de la maladie d'Alzheimer [EA 3808]
36 HLSO - Hôpital La Source [Orléans]
37 Hôpital Nord [CHU - APHM]
38 CRCINA-ÉQUIPE 17 - Design and Application of Innovative Local Treatments in Glioblastoma
39 Service Anatomie et cytologie pathologiques [CHU Toulouse]
40 MAC - Laboratoire Mouvement Adaptation Cognition
41 Service de Neurologie [Hôpitaux Civils de Colmar]
42 Cellules souches leucémiques et thérapeuthiques
43 UPD5 - Université Paris Descartes - Paris 5
44 USPC - Université Sorbonne Paris Cité
45 ACPNP - Service d'Anatomo-Cyto-Pathologie et de NeuroPathologie [Hôpital de la Timone - APHM]
Luc Bauchet
- Function : Author
- PersonId : 760714
- ORCID : 0000-0003-1077-2496
- IdRef : 085131180
Valérie Rigau
- Function : Author
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- ORCID : 0000-0002-8017-5489
- IdRef : 113707991
Aymeric Amelot
- Function : Author
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- ORCID : 0000-0003-3659-291X
Sonia Zouaoui
- Function : Author
- PersonId : 791550
- ORCID : 0000-0003-0467-3280
Agnès Caille
- Function : Author
- PersonId : 745028
- IdHAL : agnes-caille
- ORCID : 0000-0003-4715-6144
- IdRef : 133662446
Evelyne Emery
- Function : Author
- PersonId : 948145
Guillaume Gauchotte
- Function : Author
- PersonId : 999918
Catherine Godfraind
- Function : Author
- PersonId : 927173
- ORCID : 0000-0001-7336-2588
- IdRef : 17055614X
Vincent Lubrano
- Function : Author
- PersonId : 935779
- IdRef : 108136728
Emmanuel Mandonnet
- Function : Author
- PersonId : 755112
- ORCID : 0000-0003-0230-9282
- IdRef : 100933157
Philippe Menei
- Function : Author
- PersonId : 910996
- IdRef : 076585468
Serge Milin
- Function : Author
- PersonId : 922943
Audrey Rousseau
- Function : Author
- PersonId : 1040900
Stéphane Velut
- Function : Author
- PersonId : 1385942
- ORCID : 0000-0002-8961-5081
- IdRef : 033863342
Pascale Varlet
- Function : Author
- PersonId : 762020
- ORCID : 0000-0002-8164-1517
Dominique Figarella-Branger
- Function : Author
- PersonId : 18293
- IdHAL : dominique-figarella-branger
- ORCID : 0000-0002-3604-887X
- IdRef : 067213642
Johan Pallud
- Function : Author
- PersonId : 758320
- ORCID : 0000-0002-1652-9844
- IdRef : 12225225X
Ilyess Zemmoura
Connectez-vous pour contacter l'auteur
- Function : Correspondent author
- PersonId : 1098036
Connectez-vous pour contacter l'auteur
Abstract
Background - Anaplastic gangliogliomas (GGGs) are rare tumors whose natural history is poorly documented. We aimed to define their clinical and imaging features and to identify prognostic factors. Methods - Consecutive cases of anaplastic GGGs in adults prospectively entered into the French Brain Tumor Database between March 2004 and April 2014 were screened. After diagnosis was confirmed by pathological review, clinical, imaging, therapeutic, and outcome data were collected retrospectively. Results - Forty-three patients with anaplastic GGG (median age, 49.4 y) from 18 centers were included. Presenting symptoms were neurological deficit (37.2%), epileptic seizure (37.2%), or increased intracranial pressure (25.6%). Typical imaging findings were unifocal location (94.7%), contrast enhancement (88.1%), central necrosis (43.2%), and mass effect (47.6%). Therapeutic strategy included surgical resection (95.3%), adjuvant radiochemotherapy (48.8%), or radiotherapy alone (27.9%). Median progression-free survival (PFS) and overall survival (OS) were 8.0 and 24.7 months, respectively. Three- and 5-year tumor recurrence rates were 69% and 100%, respectively. The 5-year survival rate was 24.9%. Considering unadjusted significant prognostic factors, tumor midline crossing and frontal location were associated with shorter OS. Temporal and parietal locations were associated with longer and shorter PFS, respectively. None of these factors remained statistically significant in multivariate analysis. Conclusions - We report a large series providing clinical, imaging, therapeutic, and prognostic features of adult patients treated for an intracerebral anaplastic GGG. Our results show that pathological diagnosis is difficult, that survivals are only slightly better than for glioblastomas, and that complete surgical resection followed with adjuvant chemoradiotherapy offers longer survival.
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