Natural course and prognosis of anaplastic gangliogliomas: a multicenter retrospective study of 43 cases from the French Brain Tumor Database

Louis-Marie Terrier; Luc Bauchet; Valérie Rigau; Aymeric Amelot; Sonia Zouaoui; Isabelle Filipiak; Agnès Caille; Fabien Almairac; Marie-Hélène Aubriot-Lorton; Anne-Marie Bergemer-Fouquet; Eric Bord; Philippe Cornu; Alain Czorny; Phong Dam Hieu; Bertrand Debono; Marie-Bernadette Delisle; Evelyne Emery; Walid Farah; Guillaume Gauchotte; Catherine Godfraind; Jacques Guyotat; Bernard Irthum; Kevin Janot; Pierre-Jean Le Reste; Dominique Liguoro; Hugues Loiseau; Guillaume Lot; Vincent Lubrano; Emmanuel Mandonnet; Philippe Menei; Philippe Metellus; Serge Milin; Bertrand Muckenstrum; Hugues Roche; Audrey Rousseau; Emmanuel Uro-Coste; Anne Vital; Jimmy Voirin; Michel Wager; Marc Zanello; Patrick François; Stéphane Velut; Pascale Varlet; Dominique Figarella-Branger; Johan Pallud; Ilyess Zemmoura

doi:10.1093/neuonc/now186

Journal Articles Neuro-Oncology Year : 2017

Natural course and prognosis of anaplastic gangliogliomas: a multicenter retrospective study of 43 cases from the French Brain Tumor Database

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Louis-Marie Terrier

Function : Author

Luc Bauchet

Function : Author
PersonId : 760714
ORCID : 0000-0003-1077-2496

Institut des Neurosciences de Montpellier

Valérie Rigau

Function : Author

Centre référent Sclérose Latérale Amyotrophique [CHRU Montpellier]

Aymeric Amelot

Function : Author
PersonId : 777781
ORCID : 0000-0003-3659-291X

Université Paris Descartes - Faculté de Médecine

Sonia Zouaoui

Function : Author
PersonId : 791550
ORCID : 0000-0003-0467-3280

UNICANCER - Institut régional du Cancer Montpellier Val d'Aurelle

Isabelle Filipiak

Function : Author

Physiologie de la reproduction et des comportements [Nouzilly]

Agnès Caille

Function : Author
PersonId : 745028
IdHAL : agnes-caille
ORCID : 0000-0003-4715-6144
IdRef : 133662446

Centre d’Investigation Clinique [Tours] CIC 1415

Fabien Almairac

Function : Author

Institut de Biologie Valrose

Marie-Hélène Aubriot-Lorton

Function : Author

Service de Pathologie [CHU de Dijon]

Anne-Marie Bergemer-Fouquet

Function : Author

Eric Bord

Function : Author

Philippe Cornu

Function : Author
PersonId : 856089

Alain Czorny

Function : Author

Phong Dam Hieu

Function : Author

Service de neurochirurgie [Brest]

CIC Brest

Bertrand Debono

Function : Author

Service de neurochirurgie [CHU Rouen]

Marie-Bernadette Delisle

Function : Author

Service d'anatomie pathologique et histologie-cytologie [Rangueil]

Evelyne Emery

Function : Author
PersonId : 948145

Sérine protéases et physiopathologie de l'unité neurovasculaire

Walid Farah

Function : Author

Service de neurochirurgie [CHU Dijon]

Guillaume Gauchotte

Function : Author
PersonId : 999918

Centre Hospitalier Régional Universitaire de Nancy

Catherine Godfraind

Function : Author
PersonId : 927173

Laboratoire de Neuropathologie

Jacques Guyotat

Function : Author

Centre Hospitalier Lyon Sud [CHU - HCL]

Bernard Irthum

Function : Author

Service de Neurochirurgie [CHU Clermont-Ferrand]

Kevin Janot

Function : Author
PersonId : 1033962

Pierre-Jean Le Reste

Function : Author

Chemistry, Oncogenesis, Stress and Signaling

Dominique Liguoro

Function : Author

Hugues Loiseau

Function : Author

Service de neurochirurgie

Guillaume Lot

Function : Author

Vincent Lubrano

Function : Author
PersonId : 935779

Service Neurochirurgie [CHU Toulouse]

Emmanuel Mandonnet

Function : Author
PersonId : 755112
ORCID : 0000-0003-0230-9282
IdRef : 100933157

Laboratoire Kastler Brossel

Philippe Menei

Function : Author
PersonId : 910996
IdRef : 076585468

Service de neurochirurgie [CHU Angers]

Philippe Metellus

Function : Author
PersonId : 1002610

Service de neurochirurgie [CHU Marseille]

Serge Milin

Function : Author
PersonId : 922943

Cibles moléculaires et thérapeutiques de la maladie d'Alzheimer

Bertrand Muckenstrum

Function : Author

Hugues Roche

Function : Author

Audrey Rousseau

Function : Author
PersonId : 1040900

Design and Application of Innovative Local Treatments in Glioblastoma

Emmanuel Uro-Coste

Function : Author

Anne Vital

Function : Author

Laboratoire Mouvement Adaptation Cognition

Jimmy Voirin

Function : Author

Michel Wager

Function : Author
PersonId : 919915

Cellules souches leucémiques et thérapeuthiques

Marc Zanello

Function : Author

Université Paris Descartes - Paris 5

Université Sorbonne Paris Cité

Patrick François

Function : Author

Stéphane Velut

Function : Author

UMR 1253 iBrain Imagerie et cerveau

Pascale Varlet

Function : Author
PersonId : 762020
ORCID : 0000-0002-8164-1517

Université Paris Descartes - Paris 5

Université Sorbonne Paris Cité

Dominique Figarella-Branger

Function : Author
PersonId : 18293
IdHAL : dominique-figarella-branger
ORCID : 0000-0002-3604-887X
IdRef : 067213642

Service d'Anatomo-Cyto-Pathologie et de NeuroPathologie [Hôpital de la Timone - APHM]

Johan Pallud

Function : Author
PersonId : 758320
ORCID : 0000-0002-1652-9844
IdRef : 12225225X

Université Paris Descartes - Paris 5

Université Sorbonne Paris Cité

Ilyess Zemmoura

Function : Correspondent author
PersonId : 1098036

Connectez-vous pour contacter l'auteur

UMR 1253 iBrain Imagerie et cerveau

Abstract

Background - Anaplastic gangliogliomas (GGGs) are rare tumors whose natural history is poorly documented. We aimed to define their clinical and imaging features and to identify prognostic factors. Methods - Consecutive cases of anaplastic GGGs in adults prospectively entered into the French Brain Tumor Database between March 2004 and April 2014 were screened. After diagnosis was confirmed by pathological review, clinical, imaging, therapeutic, and outcome data were collected retrospectively. Results - Forty-three patients with anaplastic GGG (median age, 49.4 y) from 18 centers were included. Presenting symptoms were neurological deficit (37.2%), epileptic seizure (37.2%), or increased intracranial pressure (25.6%). Typical imaging findings were unifocal location (94.7%), contrast enhancement (88.1%), central necrosis (43.2%), and mass effect (47.6%). Therapeutic strategy included surgical resection (95.3%), adjuvant radiochemotherapy (48.8%), or radiotherapy alone (27.9%). Median progression-free survival (PFS) and overall survival (OS) were 8.0 and 24.7 months, respectively. Three- and 5-year tumor recurrence rates were 69% and 100%, respectively. The 5-year survival rate was 24.9%. Considering unadjusted significant prognostic factors, tumor midline crossing and frontal location were associated with shorter OS. Temporal and parietal locations were associated with longer and shorter PFS, respectively. None of these factors remained statistically significant in multivariate analysis. Conclusions - We report a large series providing clinical, imaging, therapeutic, and prognostic features of adult patients treated for an intracerebral anaplastic GGG. Our results show that pathological diagnosis is difficult, that survivals are only slightly better than for glioblastomas, and that complete surgical resection followed with adjuvant chemoradiotherapy offers longer survival.

Keywords

prognosis cerebral malignancy anaplastic ganglioglioma surgery

Domains

Life Sciences [q-bio] Human health and pathology Cancer Surgery

Ghislaine Calvez : Connect in order to contact the contributor

https://hal.univ-brest.fr/hal-02051153

Submitted on : Wednesday, February 27, 2019-3:42:06 PM

Last modification on : Tuesday, November 28, 2023-10:23:23 AM

Dates and versions

hal-02051153 , version 1 (27-02-2019)

Identifiers

HAL Id : hal-02051153 , version 1
DOI : 10.1093/neuonc/now186
PRODINRA : 369450
PUBMED : 28453747
PUBMEDCENTRAL : PMC5464461
WOS : 000400896500010

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Louis-Marie Terrier, Luc Bauchet, Valérie Rigau, Aymeric Amelot, Sonia Zouaoui, et al.. Natural course and prognosis of anaplastic gangliogliomas: a multicenter retrospective study of 43 cases from the French Brain Tumor Database. Neuro-Oncology, 2017, 19 (5), pp.678-688. ⟨10.1093/neuonc/now186⟩. ⟨hal-02051153⟩

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Natural course and prognosis of anaplastic gangliogliomas: a multicenter retrospective study of 43 cases from the French Brain Tumor Database

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