B cells in Sjögren’s syndrome: from pathophysiology to therapeutic target

Abstract : Biological abnormalities associated with B lymphocytes are a hallmark of patients with primary Sjögren's syndrome. Those patients present abnormal distribution of B lymphocytes in peripheral blood and B cells in exocrine glands. B cells produce auto-antibodies, cytokines and present antigens but can also suppressive functions. In this review, we will summarize current knowledge on B cells in primary Sjögren's syndrome patients, demonstrate their critical role in the immunopathology of the disease and describe the past and current trials targeting B cells.
Document type :
Journal articles
Complete list of metadatas

https://hal.univ-brest.fr/hal-02048234
Contributor : Geneviève Michel <>
Submitted on : Monday, February 25, 2019 - 2:30:31 PM
Last modification on : Tuesday, February 26, 2019 - 1:24:55 AM

Identifiers

Collections

Citation

Julie Mielle, Alice Tison, Divi Cornec, Laëtitia Le Pottier, Claire Daien, et al.. B cells in Sjögren’s syndrome: from pathophysiology to therapeutic target. Rheumatology, Oxford University Press (OUP), 2019, ⟨10.1093/rheumatology/key332⟩. ⟨hal-02048234⟩

Share

Metrics

Record views

59