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Journal Articles Rheumatology Year : 2019

B cells in Sjögren’s syndrome: from pathophysiology to therapeutic target

Abstract

Biological abnormalities associated with B lymphocytes are a hallmark of patients with primary Sjögren's syndrome. Those patients present abnormal distribution of B lymphocytes in peripheral blood and B cells in exocrine glands. B cells produce auto-antibodies, cytokines and present antigens but can also suppressive functions. In this review, we will summarize current knowledge on B cells in primary Sjögren's syndrome patients, demonstrate their critical role in the immunopathology of the disease and describe the past and current trials targeting B cells.
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hal-02048234 , version 1 (25-02-2019)

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Julie Mielle, Alice Tison, Divi Cornec, Laëtitia Le Pottier, Claire Daien, et al.. B cells in Sjögren’s syndrome: from pathophysiology to therapeutic target. Rheumatology, 2019, ⟨10.1093/rheumatology/key332⟩. ⟨hal-02048234⟩
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