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Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study

F. Balazard S. Le Fur S. Valtat A. Valleron Dominique Thevenieau Corinne Fourmy Chatel Rachel Desailloud 1 Hélène Bony-Trifunovic Pierre-Henri Ducluzeau 2 Régis Coutant 3 Sophie Caudrelier Armelle Pambou 4 Emmanuelle Dubosclard Florence Joubert 5 Philippe Jan Estelle Marcoux Anne-Marie Bertrand 6 Brigitte Mignot 7 Alfred Penformis Chantal Stuckens 8 Régis Piquemal Pascal Barat 9 Vincent Rigalleau 10 Chantal Stheneur 11 Sylviane Fournier Véronique Kerlan 12, 13 Chantal Metz Anne Fargeot-Espaliat 14 Yves Reznic Frédérique Olivier 15 Iva Gueorguieva 16 Arnaud Monier Catherine Radet Vincent Gajdos 17 Daniel Terral 18 Christine Vervel Djamel Bendifallah Candace Ben Signor 19 Daniel Dervaux Abdelkader Benmahammed Guy-André Loeuille Françoise Popelard 20 Agnès Guillou Yves Benhamou 21 Jamil Khoury Jean-Pierre Brossier Joachim Bassil 22 Sylvaine Clavel Bernard Le Luyer 23 Pierre Bougnères 24 Françoise Labay Isabelle Guemas Jacques Weill 25 Jean-Pierre Cappoen Sylvie Nadalon 26 Anne Lienhardt-Roussie 27 Anne Paoli 28 Claudie Kerouedan Edwige Yollin Marc Nicolino 29 Gilbert Simonin Jacques Cohen 30 Catherine Atlan 31 Agnès Tamboura Hervé Dubourg Marie-Laure Pignol Philippe Talon Stéphanie Jellimann Lucy Chaillous 32 Sabine Baron 33 Marie-Noëlle Bortoluzzi Elisabeth Baechler Randa Salet Ariane Zelinsky-Gurung Fabienne Dallavale Etienne Larger 34 Marie Laloi-Michelin Jean-François Gautier 35 Bénédicte Guérin Laure Oilleau Laetitia Pantalone Céline Lukas Isabelle Guilhem 36 Marc de Kerdanet 37 Marie Wielickzo Mélanie Priou-Guesdon Odile Richard 38 François Kurtz Norbert Laisney Déborah Ancelle Guilhem Guilhem Catherine Boniface Dominique Bockel Denis Dufillot Berthe Razafimahefa Pierre Gourdy 39 Pierre Lecomte 40 Myriam Pepin-Donat Emmanuelle Combes-Moukhovsky Brigitte Zymmermann Marina Raoulx Anne Dumont
Abstract : Background : The incidence of childhood type 1 diabetes (T1D) incidence is rising in many countries, supposedlybecause of changing environmental factors, which are yet largely unknown. The purpose of the study was tounravel environmental markers associated with T1D. Methods : Cases were children with T1D from the French Isis-Diab cohort. Controls were schoolmates or friends ofthe patients. Parents were asked to fill a 845-item questionnaire investigating the child’s environment before diagnosis.The analysis took into account the matching between cases and controls. A second analysis used propensity scoremethods. Results : We found a negative association of several lifestyle variables, gastroenteritis episodes, dental hygiene, hazelnutcocoa spread consumption, wasp and bee stings with T1D, consumption of vegetables from a farm and death of a petby old age. Conclusions : The found statistical association of new environmental markers with T1D calls for replication in othercohorts and investigation of new environmental areas.
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Submitted on : Monday, May 31, 2021 - 11:33:51 AM
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F. Balazard, S. Le Fur, S. Valtat, A. Valleron, Dominique Thevenieau, et al.. Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study. BMC Public Health, BioMed Central, 2016, 16 (1), ⟨10.1186/s12889-016-3690-9⟩. ⟨hal-02038642⟩

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