Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study

F. Balazard; S. Le Fur; S. Valtat; A. Valleron; Dominique Thevenieau; Corinne Fourmy Chatel; Rachel Desailloud; Hélène Bony-Trifunovic; Pierre-Henri Ducluzeau; Régis Coutant; Sophie Caudrelier; Armelle Pambou; Emmanuelle Dubosclard; Florence Joubert; Philippe Jan; Estelle Marcoux; Anne-Marie Bertrand; Brigitte Mignot; Alfred Penformis; Chantal Stuckens; Régis Piquemal; Pascal Barat; Vincent Rigalleau; Chantal Stheneur; Sylviane Fournier; Véronique Kerlan; Chantal Metz; Anne Fargeot-Espaliat; Yves Reznic; Frédérique Olivier; Iva Gueorguieva; Arnaud Monier; Catherine Radet; Vincent Gajdos; Daniel Terral; Christine Vervel; Djamel Bendifallah; Candace Ben Signor; Daniel Dervaux; Abdelkader Benmahammed; Guy-André Loeuille; Françoise Popelard; Agnès Guillou; Yves Benhamou; Jamil Khoury; Jean-Pierre Brossier; Joachim Bassil; Sylvaine Clavel; Bernard Le Luyer; Pierre Bougnères; Françoise Labay; Isabelle Guemas; Jacques Weill; Jean-Pierre Cappoen; Sylvie Nadalon; Anne Lienhardt-Roussie; Anne Paoli; Claudie Kerouedan; Edwige Yollin; Marc Nicolino; Gilbert Simonin; Jacques Cohen; Catherine Atlan; Agnès Tamboura; Hervé Dubourg; Marie-Laure Pignol; Philippe Talon; Stéphanie Jellimann; Lucy Chaillous; Sabine Baron; Marie-Noëlle Bortoluzzi; Elisabeth Baechler; Randa Salet; Ariane Zelinsky-Gurung; Fabienne Dallavale; Etienne Larger; Marie Laloi-Michelin; Jean-François Gautier; Bénédicte Guérin; Laure Oilleau; Laetitia Pantalone; Céline Lukas; Isabelle Guilhem; Marc de Kerdanet; Marie Wielickzo; Mélanie Priou-Guesdon; Odile Richard; François Kurtz; Norbert Laisney; Déborah Ancelle; Guilhem Guilhem; Catherine Boniface; Dominique Bockel; Denis Dufillot; Berthe Razafimahefa; Pierre Gourdy; Pierre B.A. Lecomte; Myriam Pepin-Donat; Emmanuelle Combes-Moukhovsky; Brigitte Zymmermann; Marina Raoulx; Anne Dumont

doi:10.1186/s12889-016-3690-9

Journal Articles BMC Public Health Year : 2016

Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study

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F. Balazard

Function : Author

S. Le Fur

Function : Author

S. Valtat

Function : Author

A. Valleron

Function : Author

Dominique Thevenieau

Function : Author

Corinne Fourmy Chatel

Function : Author

Rachel Desailloud

Function : Author
PersonId : 767326
ORCID : 0000-0001-9976-7938
IdRef : 078643422

Service d'Endocrinologie

Hélène Bony-Trifunovic

Function : Author

Pierre-Henri Ducluzeau

Function : Author
PersonId : 744425
IdHAL : pierre-henri-ducluzeau
IdRef : 074522043

Service Endocrinologie-Diabétologie

Régis Coutant

Function : Author

Endocrinologie pédiatrique[CHU Angers]

Sophie Caudrelier

Function : Author

Armelle Pambou

Function : Author

Groupe Hospitalier Artois-Ternois Centre Hospitalier d’Arras

Emmanuelle Dubosclard

Function : Author

Florence Joubert

Function : Author

Université Grenoble Alpes - UFR Médecine

Philippe Jan

Function : Author

Estelle Marcoux

Function : Author

Anne-Marie Bertrand

Function : Author

Centre Gabriel Naudé

Brigitte Mignot

Function : Author

Service de pédiatrie [CHRU Besançon]

Alfred Penformis

Function : Author

Chantal Stuckens

Function : Author

Pédiatrie-diabétologie

Régis Piquemal

Function : Author

Pascal Barat

Function : Author
PersonId : 1018712

Nutrition et Neurobiologie intégrée

Vincent Rigalleau

Function : Author

Hôpital Haut-Lévêque [CHU Bordeaux]

Chantal Stheneur

Function : Author

Consultation Marfan

Sylviane Fournier

Function : Author

Véronique Kerlan

Function : Author

Service d'Endocrinologie

Groupe d'Etude de la Thrombose de Bretagne Occidentale

Chantal Metz

Function : Author

Anne Fargeot-Espaliat

Function : Author

Pédiatrie Neonatalogie, Centre Hospitalier Général, Brive-la-Gaillarde, Brive-la-Gaillarde, France

Yves Reznic

Function : Author

Frédérique Olivier

Function : Author

Institute for Marine and Antarctic Studies [Hobart]

Iva Gueorguieva

Function : Author

Eli Lilly UK

Arnaud Monier

Function : Author

Catherine Radet

Function : Author

Vincent Gajdos

Function : Author

Centre de recherche en épidémiologie et santé des populations

Daniel Terral

Function : Author
PersonId : 776422
ORCID : 0000-0003-3706-6786

Hôtel-Dieu

Christine Vervel

Function : Author

Djamel Bendifallah

Function : Author

Candace Ben Signor

Function : Author

CHU Dijon

Daniel Dervaux

Function : Author

Abdelkader Benmahammed

Function : Author

Guy-André Loeuille

Function : Author

Françoise Popelard

Function : Author

Service de Pédiatrie

Agnès Guillou

Function : Author

Yves Benhamou

Function : Author

CHU Pitié-Salpêtrière [AP-HP]

Jamil Khoury

Function : Author

Jean-Pierre Brossier

Function : Author

Joachim Bassil

Function : Author
PersonId : 948473

Service de Pédiatrie

Sylvaine Clavel

Function : Author

Bernard Le Luyer

Function : Author

CH Le Havre

Pierre Bougnères

Function : Author

Thérapie génique, Génomique et Epigénomique

Françoise Labay

Function : Author

Isabelle Guemas

Function : Author

Jacques Weill

Function : Author

Service d'endocrinologie pédiatrique [CHU Lille]

Jean-Pierre Cappoen

Function : Author

Sylvie Nadalon

Function : Author

Service de Médecine interne A et polyclinique médicale [CHU Limoges]

Anne Lienhardt-Roussie

Function : Author
PersonId : 931417

Service de Pédiatrie médicale [CHU Limoges]

Anne Paoli

Function : Author

Laboratoire Identité Culturelle, Textes et Théâtralité

Claudie Kerouedan

Function : Author

Edwige Yollin

Function : Author

Marc Nicolino

Function : Author

Service d'endocrinologie pédiatrique [CHU Lyon-Hospices Civils de Lyon]

Gilbert Simonin

Function : Author

Jacques Cohen

Function : Author

Institut d'Informatique et de Mathématiques Appliquées de Grenoble

Catherine Atlan

Function : Author
PersonId : 925765

Centre d'Etudes des Mondes Africains

Agnès Tamboura

Function : Author

Hervé Dubourg

Function : Author

Marie-Laure Pignol

Function : Author

Philippe Talon

Function : Author

Stéphanie Jellimann

Function : Author

Lucy Chaillous

Function : Author

Clinique d'Endocrinologie, Maladies Métaboliques et Nutrition

Sabine Baron

Function : Author

Service d'Endocrinologie Pédiatrique [CHU Nantes]

Marie-Noëlle Bortoluzzi

Function : Author

Elisabeth Baechler

Function : Author

Randa Salet

Function : Author

Ariane Zelinsky-Gurung

Function : Author

Fabienne Dallavale

Function : Author

Etienne Larger

Function : Author
PersonId : 765206
ORCID : 0000-0002-1017-1845

Department of diabetes

Marie Laloi-Michelin

Function : Author

Jean-François Gautier

Function : Author
PersonId : 973211

Chu (saint-Louis)/inserm

Bénédicte Guérin

Function : Author

Laure Oilleau

Function : Author

Laetitia Pantalone

Function : Author

Céline Lukas

Function : Author

Isabelle Guilhem

Function : Author

Centre Hospitalier Universitaire [Rennes]

Marc de Kerdanet

Function : Author

Service de Pédiatrie

Marie Wielickzo

Function : Author

Mélanie Priou-Guesdon

Function : Author

Odile Richard

Function : Author

François Kurtz

Function : Author

Norbert Laisney

Function : Author

Déborah Ancelle

Function : Author

Guilhem Guilhem

Function : Author

Catherine Boniface

Function : Author

Dominique Bockel

Function : Author

Denis Dufillot

Function : Author

Berthe Razafimahefa

Function : Author

Pierre Gourdy

Function : Author
PersonId : 862556

Service Diabétologie [CHU Toulouse]

Pierre B.A. Lecomte

Function : Author
PersonId : 885215

Geothalg

Myriam Pepin-Donat

Function : Author

Emmanuelle Combes-Moukhovsky

Function : Author

Brigitte Zymmermann

Function : Author

Marina Raoulx

Function : Author

Anne Dumont

Function : Author

Abstract

Background : The incidence of childhood type 1 diabetes (T1D) incidence is rising in many countries, supposedlybecause of changing environmental factors, which are yet largely unknown. The purpose of the study was tounravel environmental markers associated with T1D. Methods : Cases were children with T1D from the French Isis-Diab cohort. Controls were schoolmates or friends ofthe patients. Parents were asked to fill a 845-item questionnaire investigating the child’s environment before diagnosis.The analysis took into account the matching between cases and controls. A second analysis used propensity scoremethods. Results : We found a negative association of several lifestyle variables, gastroenteritis episodes, dental hygiene, hazelnutcocoa spread consumption, wasp and bee stings with T1D, consumption of vegetables from a farm and death of a petby old age. Conclusions : The found statistical association of new environmental markers with T1D calls for replication in othercohorts and investigation of new environmental areas.

Keywords

Case–control Epidemiology Type 1 diabetes Data-driven Environment

Domains

Life Sciences [q-bio] Human health and pathology Endocrinology and metabolism

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Origin : Publication funded by an institution

Ghislaine Calvez : Connect in order to contact the contributor

https://hal.univ-brest.fr/hal-02038642

Submitted on : Monday, May 31, 2021-11:33:51 AM

Last modification on : Friday, November 24, 2023-1:36:05 PM

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hal-02038642 , version 1 (31-05-2021)

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HAL Id : hal-02038642 , version 1
DOI : 10.1186/s12889-016-3690-9
PUBMED : 27682602
PUBMEDCENTRAL : PMC5041527

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F. Balazard, S. Le Fur, S. Valtat, A. Valleron, Dominique Thevenieau, et al.. Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study. BMC Public Health, 2016, 16 (1), ⟨10.1186/s12889-016-3690-9⟩. ⟨hal-02038642⟩

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Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study

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