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Journal Articles European Journal of Medicinal Chemistry Year : 1998

Phosphonolipids as non-viral vectors for gene therapy

Abstract

Several phosphonates with two fatty chains and different polar heads were synthesized and evaluated for their potential to transfer DNA into epithelial (COS-7) and hematopoietic (K562) cell lines, and compared to commercially available references. In both cases, ammonium-phosphonates were particularly efficient.

Dates and versions

hal-01770726 , version 1 (19-04-2018)

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V. Floch, G. Le Bolc'H, C. Gable-Guillaume, Nathalie Le Bris, J.-J. Yaouanc, et al.. Phosphonolipids as non-viral vectors for gene therapy. European Journal of Medicinal Chemistry, 1998, 33, pp.923--934. ⟨10.1016/S0223-5234(99)80017-8⟩. ⟨hal-01770726⟩
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