Phosphonolipids as non-viral vectors for gene therapy

V. Floch; G. Le Bolc'H; C. Gable-Guillaume; Nathalie Le Bris; J.-J. Yaouanc; H. Des Abbayes; C. Férec; J.-C. Clément

doi:10.1016/S0223-5234(99)80017-8

Journal articles

Phosphonolipids as non-viral vectors for gene therapy

V. Floch G. Le Bolc'H C. Gable-Guillaume Nathalie Le Bris ¹ J.-J. Yaouanc ¹ H. Des Abbayes ¹ C. Férec ² J.-C. Clément ¹

1 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique

2 Génétique moléculaire et génétique épidémiologique

Abstract : Several phosphonates with two fatty chains and different polar heads were synthesized and evaluated for their potential to transfer DNA into epithelial (COS-7) and hematopoietic (K562) cell lines, and compared to commercially available references. In both cases, ammonium-phosphonates were particularly efficient.

Keywords : Ammoniums Non-vital transfection Phosphonolipids Polyamines

Document type :

Journal articles

Domain :

Chemical Sciences

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https://hal.univ-brest.fr/hal-01770726
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Submitted on : Thursday, April 19, 2018 - 10:58:10 AM
Last modification on : Monday, October 11, 2021 - 2:22:16 PM

Phosphonolipids as non-viral vectors for gene therapy

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