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Phosphonolipids as non-viral vectors for gene therapy

V. Floch G. Le Bolc'H C. Gable-Guillaume Nathalie Le Bris 1 J.-J. Yaouanc 1 H. Des Abbayes 1 C. Férec 2 J.-C. Clément 1
1 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique
2 Génétique moléculaire et génétique épidémiologique
Abstract : Several phosphonates with two fatty chains and different polar heads were synthesized and evaluated for their potential to transfer DNA into epithelial (COS-7) and hematopoietic (K562) cell lines, and compared to commercially available references. In both cases, ammonium-phosphonates were particularly efficient.
Keywords : Ammoniums Non-vital transfection Phosphonolipids Polyamines
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https://hal.univ-brest.fr/hal-01770726
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Submitted on : Thursday, April 19, 2018 - 10:58:10 AM
Last modification on : Thursday, November 29, 2018 - 4:09:10 PM

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V. Floch, G. Le Bolc'H, C. Gable-Guillaume, Nathalie Le Bris, J.-J. Yaouanc, et al.. Phosphonolipids as non-viral vectors for gene therapy. European Journal of Medicinal Chemistry, Elsevier, 1998, 33, pp.923--934. ⟨10.1016/S0223-5234(99)80017-8⟩. ⟨hal-01770726⟩

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