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Stoichiometric mono N-functionalization of cyclen via a boron protected intermediate

F. Chuburu M. Le Baccon Henri Handel 1 
1 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique
Abstract : The temporary triprotection of cyclen by a boron atom performed in presence of sodium hydride offers a convenient solution for the mono N-alkylation of cyclen. Examples of mono N-alkylated cyclens and bis-cyclens are reported. © 2001 Elsevier Science Ltd.
Keywords : 1 7 10 tetraazacyclododecane boron carbon nitrogen monocycle cyclam sodium derivative sodium hydride unclassified drug alkylation article chemical reaction chemical structure priority journal reaction analysis stoichiometry
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Journal articles
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https://hal.univ-brest.fr/hal-01770126
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Submitted on : Wednesday, April 18, 2018 - 4:15:30 PM
Last modification on : Monday, October 11, 2021 - 2:22:08 PM

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F. Chuburu, M. Le Baccon, Henri Handel. Stoichiometric mono N-functionalization of cyclen via a boron protected intermediate. Tetrahedron, Elsevier, 2001, 57 (12), pp.2385-2390. ⟨10.1016/S0040-4020(01)00115-6⟩. ⟨hal-01770126⟩

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