A new versatile synthesis of macrotricyclic tetraazacycloalkane-based ligands from bis-aminal derivatives

S. Develay; Raphaël Tripier; F. Chuburu; M. Le Baccon; Henri Handel

Journal articles

A new versatile synthesis of macrotricyclic tetraazacycloalkane-based ligands from bis-aminal derivatives

S. Develay Raphaël Tripier ¹ F. Chuburu M. Le Baccon Henri Handel ¹

1 CEMCA - Chimie, Electrochimie Moléculaires et Chimie Analytique

Abstract : A new powerful synthesis of symmetrical (two-step) or dissymmetrical (three-step) macrotricyclic cyclen- or cyclam-based ligands is reported. In this procedure, the starting materials are bis-aminals derived from condensation of cyclen or cyclam with glyoxal. The two macrocyclic subunits are linked by two aromatic spacers through nitrogen atoms. © Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Keywords : alkane derivative bisaminal derivative cyclam glyoxal heterocyclic amine ligand nitrogen unclassified drug alkylation article chemical structure polymerization reaction analysis structure analysis synthesis

Document type :

Journal articles

Domain :

Chemical Sciences

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https://hal.univ-brest.fr/hal-01763899
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Submitted on : Wednesday, April 11, 2018 - 2:59:15 PM
Last modification on : Friday, February 22, 2019 - 4:56:08 PM

A new versatile synthesis of macrotricyclic tetraazacycloalkane-based ligands from bis-aminal derivatives

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A new versatile synthesis of macrotricyclic tetraazacycloalkane-based ligands from bis-aminal derivatives

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